Arteriolar remodeling in essential hypertension: are connective tissue growth factor and transforming growth factor involved?

• Published in: Kidney international Vol. 69; no. 7; pp. 1104 - 1105
• Main Author: Rodriguez-Iturbe, B.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.04.2006; Elsevier Limited
• Subjects: Amlodipine - adverse effects; Antihypertensive Agents - adverse effects; Antihypertensive Agents - therapeutic use; Arterioles - physiopathology; Connective Tissue Growth Factor; Humans; Hypertension - drug therapy; Hypertension - physiopathology; Immediate-Early Proteins - physiology; Intercellular Signaling Peptides and Proteins - physiology; Losartan - therapeutic use; Transforming Growth Factor beta - physiology

Gómez-Garre et al. report increased expression of connective tissue growth factor and transforming growth factor-β and worsening of remodeling in subcutaneous arterioles of patients with essential hypertension during amlodipine treatment. Losartan improves remodeling without changes in cytokine expr...