Arteriolar remodeling in essential hypertension: are connective tissue growth factor and transforming growth factor involved?

Gómez-Garre et al. report increased expression of connective tissue growth factor and transforming growth factor-β and worsening of remodeling in subcutaneous arterioles of patients with essential hypertension during amlodipine treatment. Losartan improves remodeling without changes in cytokine expr...

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Bibliographic Details
Published inKidney international Vol. 69; no. 7; pp. 1104 - 1105
Main Author Rodriguez-Iturbe, B.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.04.2006
Elsevier Limited
Subjects
Amlodipine - adverse effects
Antihypertensive Agents - adverse effects
Antihypertensive Agents - therapeutic use
Arterioles - physiopathology
Connective Tissue Growth Factor
Humans
Hypertension - drug therapy
Hypertension - physiopathology
Immediate-Early Proteins - physiology
Intercellular Signaling Peptides and Proteins - physiology
Losartan - therapeutic use
Transforming Growth Factor beta - physiology
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Summary:Gómez-Garre et al. report increased expression of connective tissue growth factor and transforming growth factor-β and worsening of remodeling in subcutaneous arterioles of patients with essential hypertension during amlodipine treatment. Losartan improves remodeling without changes in cytokine expression. The discordant effects of two well-accepted treatments for hypertension underline the need for further studies on therapy-induced changes in arteriolar remodeling.
ISSN:0085-2538
1523-1755
DOI:10.1038/sj.ki.5000222