Pharmacokinetics of TCDD in veterans of Operation Ranch Hand: 10-year follow-up

Using multiple measurements from serum collected over 10 yr (1982, 1987, and 1992), we estimated the half-life of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in 213 veterans of Operation Ranch Hand, the Air Force unit responsible for the aerial spraying of Agent Orange in Vietnam. The potential influ...

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Published inJournal of toxicology and environmental health Vol. 47; no. 3; pp. 209 - 220
Main Authors Michalek, J.E, Pirkle, J.L, Caudill, S.P, Tripathi, R.C, Patterson, D.G. Jr, Needham, L.L
Format Journal Article
LanguageEnglish
Published United States 23.02.1996
Subjects
2,3,7,8-tetrachlorodibenzo-p-dioxin
Adipose Tissue - anatomy & histology
Adipose Tissue - metabolism
age
Aging - metabolism
blood serum
body fat
contaminants
dioxin
Follow-Up Studies
Half-Life
herbicide impurities
Humans
Military Personnel
Occupational Exposure
organochlorine compounds
pharmacokinetics
Polychlorinated Dibenzodioxins - pharmacokinetics
Regression Analysis
United States
Veterans
vietnam veterans
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Summary:Using multiple measurements from serum collected over 10 yr (1982, 1987, and 1992), we estimated the half-life of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in 213 veterans of Operation Ranch Hand, the Air Force unit responsible for the aerial spraying of Agent Orange in Vietnam. The potential influences of age, percent body fat, and changes in percent body fat on the half-life estimate were also examined. The mean decay rate of TCDD for these veterans is 0.0797 per year with 95% confidence interval 0.0727 to 0.0868 per year; the corresponding half-life estimate is 8.7 yr with 95% confidence interval 8.0-9.5 yr. Half-life increased significantly with increasing body fat, but not with age or relative changes in percent body fat.
ISSN:0098-4108
1087-2620
DOI:10.1080/009841096161744