All purpose Sox: The many roles of Sox proteins in gene expression

Sox proteins are found in all metazoans and are active in many developmental processes. Their function as transcription factors is governed by their DNA-binding properties as much as by their interactions with other transcription factors and cofactors, and subject to modulation by posttranslational...

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Bibliographic Details
Published inThe international journal of biochemistry & cell biology Vol. 42; no. 3; pp. 381 - 390
Main Author Wegner, Michael
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier Ltd 01.03.2010
Subjects
Animals
Coactivator
Gene Expression Regulation
High-mobility-group
Humans
SOX Transcription Factors - chemistry
SOX Transcription Factors - genetics
SOX Transcription Factors - metabolism
Sry-box
Transactivation
Transcriptional repression
Coactivator
Sry-box
High-mobility-group
Transactivation
Transcriptional repression
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Summary:Sox proteins are found in all metazoans and are active in many developmental processes. Their function as transcription factors is governed by their DNA-binding properties as much as by their interactions with other transcription factors and cofactors, and subject to modulation by posttranslational modifications. Although most Sox proteins predominantly function as transcriptional activators, there is also evidence for transcriptional repression and architectural roles. Further effects involve complex formation of Sox proteins with transcriptionally relevant factors off DNA. Sox proteins may be additionally active on the posttranscriptional level and are therefore remarkably versatile regulators of gene expression.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:1357-2725
1878-5875
1878-5875
DOI:10.1016/j.biocel.2009.07.006