Impact of target reproducibility on tumor dose in stereotactic radiotherapy of targets in the lung and liver
Background and purpose: Previous analyses of target reproducibility in extracranial stereotactic radiotherapy have revealed standard security margins for planning target volume (PTV) definition of 5 mm in axial and 5–10 mm in longitudinal direction. In this study the reproducibility of the clinical...
Saved in:
Published in | Radiotherapy and oncology Vol. 66; no. 2; pp. 141 - 150 |
---|---|
Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
Ireland
Elsevier Ireland Ltd
01.02.2003
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | Background and purpose: Previous analyses of target reproducibility in extracranial stereotactic radiotherapy have revealed standard security margins for planning target volume (PTV) definition of 5
mm in axial and 5–10
mm in longitudinal direction. In this study the reproducibility of the clinical target volume (CTV) of lung and liver tumors within the PTV over the complete course of hypofractionated treatment is evaluated. The impact of target mobility on dose to the CTV is assessed by dose–volume histograms (DVH).
Materials and methods: Twenty-two pulmonary and 21 hepatic targets were treated with three stereotactic fractions of 10
Gy to the PTV-enclosing 100%-isodose with normalization to 150% at the isocenter. A conformal dose distribution was related to the PTV, which was defined by margins of 5–10
mm added to the CTV. Prior to each fraction a computed tomography (CT)-simulation over the complete target volume was performed resulting in a total of 60 CT-simulations for lung and 58 CT-simulations for hepatic targets. The CTV from each CT-simulation was segmented and matched with the CT-study used for treatment planning. A DVH of the simulated CTV was calculated for each fraction. The target coverage (TC) of dose to the simulated CTV was defined as the proportion of the CTV receiving at least the reference dose (100%).
Results: A decrease of TC to <95% was found in 3/60 simulations (5%) of pulmonary and 7/58 simulations (12%) of hepatic targets. In two of 22 pulmonary targets (9%) and in four of 21 hepatic targets (19%) a TC of <95% occurred in at least one fraction. At risk for a decreased TC <95% were pulmonary targets with increased breathing mobility and hepatic targets with a CTV exceeding 100
cm
3.
Conclusions: Target reproducibility was precise within the reference isodose in 91% of lung and 81% of liver tumors with a TC of the complete CTV ≥95% at each fraction of treatment. Pulmonary targets with increased breathing mobility and liver tumors >100
cm
3 are at risk for target deviation exceeding the standard security margins for PTV-definition at least for one fraction and require individual evaluation of sufficient margins. |
---|---|
AbstractList | Previous analyses of target reproducibility in extracranial stereotactic radiotherapy have revealed standard security margins for planning target volume (PTV) definition of 5mm in axial and 5-10mm in longitudinal direction. In this study the reproducibility of the clinical target volume (CTV) of lung and liver tumors within the PTV over the complete course of hypofractionated treatment is evaluated. The impact of target mobility on dose to the CTV is assessed by dose-volume histograms (DVH).
Twenty-two pulmonary and 21 hepatic targets were treated with three stereotactic fractions of 10 Gy to the PTV-enclosing 100%-isodose with normalization to 150% at the isocenter. A conformal dose distribution was related to the PTV, which was defined by margins of 5-10mm added to the CTV. Prior to each fraction a computed tomography (CT)-simulation over the complete target volume was performed resulting in a total of 60 CT-simulations for lung and 58 CT-simulations for hepatic targets. The CTV from each CT-simulation was segmented and matched with the CT-study used for treatment planning. A DVH of the simulated CTV was calculated for each fraction. The target coverage (TC) of dose to the simulated CTV was defined as the proportion of the CTV receiving at least the reference dose (100%).
A decrease of TC to <95% was found in 3/60 simulations (5%) of pulmonary and 7/58 simulations (12%) of hepatic targets. In two of 22 pulmonary targets (9%) and in four of 21 hepatic targets (19%) a TC of <95% occurred in at least one fraction. At risk for a decreased TC <95% were pulmonary targets with increased breathing mobility and hepatic targets with a CTV exceeding 100 cm(3).
Target reproducibility was precise within the reference isodose in 91% of lung and 81% of liver tumors with a TC of the complete CTV >or=95% at each fraction of treatment. Pulmonary targets with increased breathing mobility and liver tumors >100 cm(3) are at risk for target deviation exceeding the standard security margins for PTV-definition at least for one fraction and require individual evaluation of sufficient margins. Background and purpose: Previous analyses of target reproducibility in extracranial stereotactic radiotherapy have revealed standard security margins for planning target volume (PTV) definition of 5 mm in axial and 5–10 mm in longitudinal direction. In this study the reproducibility of the clinical target volume (CTV) of lung and liver tumors within the PTV over the complete course of hypofractionated treatment is evaluated. The impact of target mobility on dose to the CTV is assessed by dose–volume histograms (DVH). Materials and methods: Twenty-two pulmonary and 21 hepatic targets were treated with three stereotactic fractions of 10 Gy to the PTV-enclosing 100%-isodose with normalization to 150% at the isocenter. A conformal dose distribution was related to the PTV, which was defined by margins of 5–10 mm added to the CTV. Prior to each fraction a computed tomography (CT)-simulation over the complete target volume was performed resulting in a total of 60 CT-simulations for lung and 58 CT-simulations for hepatic targets. The CTV from each CT-simulation was segmented and matched with the CT-study used for treatment planning. A DVH of the simulated CTV was calculated for each fraction. The target coverage (TC) of dose to the simulated CTV was defined as the proportion of the CTV receiving at least the reference dose (100%). Results: A decrease of TC to <95% was found in 3/60 simulations (5%) of pulmonary and 7/58 simulations (12%) of hepatic targets. In two of 22 pulmonary targets (9%) and in four of 21 hepatic targets (19%) a TC of <95% occurred in at least one fraction. At risk for a decreased TC <95% were pulmonary targets with increased breathing mobility and hepatic targets with a CTV exceeding 100 cm 3. Conclusions: Target reproducibility was precise within the reference isodose in 91% of lung and 81% of liver tumors with a TC of the complete CTV ≥95% at each fraction of treatment. Pulmonary targets with increased breathing mobility and liver tumors >100 cm 3 are at risk for target deviation exceeding the standard security margins for PTV-definition at least for one fraction and require individual evaluation of sufficient margins. |
Author | Wulf, Jörn Thiele, Wibke Oppitz, Ulrich Hädinger, Ulrich Flentje, Michael |
Author_xml | – sequence: 1 givenname: Jörn surname: Wulf fullname: Wulf, Jörn – sequence: 2 givenname: Ulrich surname: Hädinger fullname: Hädinger, Ulrich – sequence: 3 givenname: Ulrich surname: Oppitz fullname: Oppitz, Ulrich – sequence: 4 givenname: Wibke surname: Thiele fullname: Thiele, Wibke – sequence: 5 givenname: Michael surname: Flentje fullname: Flentje, Michael |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/12648785$$D View this record in MEDLINE/PubMed |
BookMark | eNqFkE1LxDAQhoMourv6E5Qc9VCdpB9JTyLiFyx4cO8hTaYa6TYlSYX993Z3RY9eZmB43pnhmZPD3vdIyDmDawasunmbisgkK-AS-BVALnhWH5AZk6LOQEpxSGa_yAmZx_gJAHzijskJ41UhhSxnpHtZD9ok6luadHjHRAMOwdvRuMZ1Lm2o72ka1z5Q6yNS19OYMKBPU8oZGrR1Pn1g0MPmb0ncctOUdmP_TnVvaee-MJySo1Z3Ec9--oKsHh9W98_Z8vXp5f5umZmCi5RpxtDmumVNBVK3wlRNLlpZMaYrWYKeBjxHjoW0tWzzRrSgEWXNBZTQlPmClPu1JvgYA7ZqCG6tw0YxUFt5aidPbc0o4GonT9VT7mKfG8ZmjfYv9WNrAm73AE7PfzkMKhqHvUHrApqkrHf_nPgGHkiCZg |
CitedBy_id | crossref_primary_10_1016_j_ijrobp_2007_04_074 crossref_primary_10_1016_j_ijrobp_2004_02_060 crossref_primary_10_1016_j_ijrobp_2008_06_1939 crossref_primary_10_1120_jacmp_v15i2_4418 crossref_primary_10_1016_j_lungcan_2007_10_005 crossref_primary_10_1007_s11548_008_0246_1 crossref_primary_10_1088_1742_6596_250_1_012057 crossref_primary_10_1118_1_2739811 crossref_primary_10_1016_j_ijrobp_2006_11_025 crossref_primary_10_1007_s00066_013_0450_y crossref_primary_10_1177_1533034615596273 crossref_primary_10_1016_j_ijrobp_2004_12_075 crossref_primary_10_1016_j_lungcan_2004_07_982 crossref_primary_10_1016_j_ijrobp_2008_03_032 crossref_primary_10_1186_1748_717X_1_45 crossref_primary_10_1007_s00066_011_2236_4 crossref_primary_10_1016_j_ijrobp_2006_12_034 crossref_primary_10_1007_s00066_014_0688_z crossref_primary_10_1016_j_radonc_2008_08_010 crossref_primary_10_1586_14737140_8_1_87 crossref_primary_10_1016_j_radonc_2007_10_044 crossref_primary_10_1177_153303460800700103 crossref_primary_10_1007_s13566_020_00417_z crossref_primary_10_1080_02841860600911172 crossref_primary_10_1016_j_radonc_2006_08_006 crossref_primary_10_1038_nrclinonc_2012_166 crossref_primary_10_1016_j_ijrobp_2006_12_022 crossref_primary_10_1016_j_radonc_2005_09_003 crossref_primary_10_1016_j_radonc_2007_01_012 crossref_primary_10_1186_1748_717X_5_32 crossref_primary_10_1016_j_ijrobp_2007_09_036 crossref_primary_10_1016_j_radonc_2008_08_003 crossref_primary_10_1186_1748_717X_6_107 crossref_primary_10_1007_BF02712383 crossref_primary_10_1016_j_radonc_2003_10_013 crossref_primary_10_1016_j_ijrobp_2006_03_057 crossref_primary_10_1155_2014_136513 crossref_primary_10_1016_j_ijrobp_2009_08_033 crossref_primary_10_1080_02841860600907345 crossref_primary_10_1016_j_radonc_2005_04_018 crossref_primary_10_1177_153303460600500102 crossref_primary_10_1016_j_radonc_2008_06_001 crossref_primary_10_1016_j_ijrobp_2006_11_018 crossref_primary_10_1186_1748_717X_5_24 crossref_primary_10_1097_01_RVI_0000142599_48497_6B crossref_primary_10_1155_2015_653974 crossref_primary_10_1120_jacmp_v15i2_4042 crossref_primary_10_1097_01_coc_0000236210_41199_91 crossref_primary_10_1016_j_ijrobp_2006_06_018 crossref_primary_10_1120_jacmp_v13i2_3708 crossref_primary_10_3233_XST_17303 crossref_primary_10_1186_1748_717X_1_30 crossref_primary_10_1186_1748_717X_9_210 crossref_primary_10_1016_j_ijrobp_2004_03_028 crossref_primary_10_1177_153303460700600409 crossref_primary_10_1080_02841860600904821 |
Cites_doi | 10.1016/S0360-3016(99)00413-7 10.3109/02841869309093624 10.1016/S0167-8140(99)00037-7 10.3109/02841869509127197 10.3109/02841869409121782 10.1200/JCO.2001.19.1.164 10.1016/S0360-3016(96)00601-3 10.1023/B:JORA.0000010880.40483.c4 10.1016/S0360-3016(00)00619-2 10.1016/S0167-8140(00)00226-7 10.1016/S0167-8140(98)00140-6 10.1023/B:JORA.0000010898.87146.2e 10.1016/S0360-3016(01)01641-8 10.1016/S0360-3016(00)00617-9 10.1002/(SICI)1097-0142(19980315)82:6<1062::AID-CNCR8>3.0.CO;2-G 10.1016/S0360-3016(99)00056-5 10.1007/PL00002379 |
ContentType | Journal Article |
Copyright | 2002 Elsevier Science Ireland Ltd |
Copyright_xml | – notice: 2002 Elsevier Science Ireland Ltd |
DBID | CGR CUY CVF ECM EIF NPM AAYXX CITATION |
DOI | 10.1016/S0167-8140(02)00372-9 |
DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef |
DatabaseTitleList | MEDLINE |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Medicine |
EISSN | 1879-0887 |
EndPage | 150 |
ExternalDocumentID | 10_1016_S0167_8140_02_00372_9 12648785 S0167814002003729 |
Genre | Validation Studies Journal Article |
GroupedDBID | --- --K --M .1- .55 .FO .GJ .~1 0R~ 0SF 123 1B1 1P~ 1RT 1~. 1~5 29P 4.4 457 4G. 53G 5RE 5VS 7-5 71M 8P~ 9JM AABNK AACTN AAEDT AAEDW AAIAV AAIKJ AAKOC AALRI AAOAW AAQFI AAQXK AAXUO ABBQC ABFNM ABJNI ABLVK ABMAC ABMZM ABOCM ABUDA ABXDB ABYKQ ACDAQ ACGFS ACIUM ACRLP ADBBV ADEZE ADMUD AEBSH AEHWI AEKER AENEX AEVXI AFCTW AFKWA AFRHN AFTJW AFXIZ AGHFR AGUBO AGYEJ AHHHB AHPSJ AIEXJ AIKHN AITUG AJBFU AJOXV AJRQY AJUYK ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ ANZVX ASPBG AVWKF AXJTR AZFZN BKOJK BLXMC BNPGV CS3 DU5 E3Z EBS EFJIC EFLBG EJD EO8 EO9 EP2 EP3 F5P FDB FEDTE FGOYB FIRID FNPLU FYGXN G-2 G-Q GBLVA HED HMK HMO HVGLF HZ~ IHE J1W J5H KOM LCYCR M27 M41 MO0 N9A NCXOZ O-L O9- OAUVE OC~ OO- OZT P-8 P-9 P2P PC. Q38 R2- RIG ROL RPZ SAE SDF SDG SEL SES SEW SPCBC SSH SSU SSZ T5K UV1 WUQ X7M Z5R ZGI ZXP ~G- AKRWK CGR CUY CVF ECM EIF NPM AAXKI AAYXX ADVLN CITATION |
ID | FETCH-LOGICAL-c427t-a11ed3af1b608af7c6b37f8611a6850a7c623e2e48d98f3b7f0aee8927050b53 |
IEDL.DBID | .~1 |
ISSN | 0167-8140 |
IngestDate | Thu Sep 12 18:28:21 EDT 2024 Thu May 23 23:49:28 EDT 2024 Fri Feb 23 02:11:20 EST 2024 |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 2 |
Keywords | Conformal radiotherapy Stereotactic body frame Computed tomography simulation Treatment accuracy Stereotactic radiotherapy Dose–volume histogram |
Language | English |
LinkModel | DirectLink |
MergedId | FETCHMERGED-LOGICAL-c427t-a11ed3af1b608af7c6b37f8611a6850a7c623e2e48d98f3b7f0aee8927050b53 |
PMID | 12648785 |
PageCount | 10 |
ParticipantIDs | crossref_primary_10_1016_S0167_8140_02_00372_9 pubmed_primary_12648785 elsevier_sciencedirect_doi_10_1016_S0167_8140_02_00372_9 |
PublicationCentury | 2000 |
PublicationDate | 2003-02-01 |
PublicationDateYYYYMMDD | 2003-02-01 |
PublicationDate_xml | – month: 02 year: 2003 text: 2003-02-01 day: 01 |
PublicationDecade | 2000 |
PublicationPlace | Ireland |
PublicationPlace_xml | – name: Ireland |
PublicationTitle | Radiotherapy and oncology |
PublicationTitleAlternate | Radiother Oncol |
PublicationYear | 2003 |
Publisher | Elsevier Ireland Ltd |
Publisher_xml | – name: Elsevier Ireland Ltd |
References | Blomgren, Lax, Näslund, Svanström (BIB1) 1995; 34 Lax, Blomgren, Larson, Näslund (BIB7) 1998; 1 Van't Riet, Mak, Moerland, Elders, Van der Zee (BIB15) 1997; 37 Herfarth, Debus, Lohr (BIB4) 2001; 19 Wulf, Haedinger, Oppitz, Thiele, Ness-Dourdoumas, Flentje (BIB18) 2001; 177 Lax, Blomgren, Näslund, Svanström (BIB6) 1994; 33 Nakagawa, Aoki, Tago, Terahara, Ohtomo (BIB8) 2000; 48 Wulf, Haedinger, Oppitz, Olshausen, Flentje (BIB17) 2000; 57 Uematsu, Sonderegger, Shioda (BIB13) 1999; 50 StatSoft, Inc. STATISTICA für Windows [Computer- Programm-Handbuch]. StatSoft, Inc., 2300 East 14th Street, Tulsa, OK 74104, Tel.: +1-918-749-1119, fax: +1-918-749-2217, e-mail: info@statsoft.com, WEB: http://www.statsoft.com. Tulsa, OK, 1998. Shimizu, Shirato, Ogura (BIB10) 2001; 51 Blomgren, Lax, Göranson (BIB2) 1998; 1 Lax (BIB5) 1993; 32 Shimizu, Shirato, Xo (BIB9) 1999; 50 Uematsu, Shioda, Tahara (BIB12) 1998; 82 Herfarth, Debus, Lohr (BIB3) 2000; 46 Wong, Sharpe, Jaffray (BIB16) 1999; 44 Uematsu, Shioda, Suda (BIB14) 2000; 48 Shimizu (10.1016/S0167-8140(02)00372-9_BIB10) 2001; 51 Lax (10.1016/S0167-8140(02)00372-9_BIB6) 1994; 33 Wulf (10.1016/S0167-8140(02)00372-9_BIB18) 2001; 177 Herfarth (10.1016/S0167-8140(02)00372-9_BIB3) 2000; 46 Wong (10.1016/S0167-8140(02)00372-9_BIB16) 1999; 44 Herfarth (10.1016/S0167-8140(02)00372-9_BIB4) 2001; 19 Uematsu (10.1016/S0167-8140(02)00372-9_BIB12) 1998; 82 Lax (10.1016/S0167-8140(02)00372-9_BIB5) 1993; 32 Blomgren (10.1016/S0167-8140(02)00372-9_BIB1) 1995; 34 10.1016/S0167-8140(02)00372-9_BIB11 Nakagawa (10.1016/S0167-8140(02)00372-9_BIB8) 2000; 48 Shimizu (10.1016/S0167-8140(02)00372-9_BIB9) 1999; 50 Blomgren (10.1016/S0167-8140(02)00372-9_BIB2) 1998; 1 Wulf (10.1016/S0167-8140(02)00372-9_BIB17) 2000; 57 Uematsu (10.1016/S0167-8140(02)00372-9_BIB14) 2000; 48 Uematsu (10.1016/S0167-8140(02)00372-9_BIB13) 1999; 50 Lax (10.1016/S0167-8140(02)00372-9_BIB7) 1998; 1 Van't Riet (10.1016/S0167-8140(02)00372-9_BIB15) 1997; 37 |
References_xml | – volume: 1 start-page: 135 year: 1998 end-page: 148 ident: BIB7 article-title: Extracranial stereotactic radiosurgery of localized targets publication-title: J Radiosurg contributor: fullname: Näslund – volume: 48 start-page: 443 year: 2000 end-page: 448 ident: BIB14 article-title: Intrafractional tumor position stability during computed tomography (CT)-guided frameless stereotactic radiation therapy for lung or liver cancers with a fusion of CT and linear accelerator (focal) unit publication-title: Int J Radiat Oncol Biol Phys contributor: fullname: Suda – volume: 44 start-page: 911 year: 1999 end-page: 919 ident: BIB16 article-title: The use of active breathing control (ABC) to reduce margin for breathing motion publication-title: Int J Radiat Oncol Biol Phys contributor: fullname: Jaffray – volume: 177 start-page: 645 year: 2001 end-page: 655 ident: BIB18 article-title: Stereotactic radiotherapy of targets in the lung and liver publication-title: Strahlenther Onkol contributor: fullname: Flentje – volume: 50 start-page: 337 year: 1999 end-page: 339 ident: BIB13 article-title: Daily positioning accuracy of frameless stereotatctic radiation therapy with a fusion of computed tomography and linear accellarator (focal) unit: evaluation of z-axis with a z-marker publication-title: Radiother Oncol contributor: fullname: Shioda – volume: 82 start-page: 1062 year: 1998 end-page: 1070 ident: BIB12 article-title: Focal, high dose, and fractionated modified stereotactic radiation therapy for lung carcinoma patients publication-title: Cancer contributor: fullname: Tahara – volume: 32 start-page: 453 year: 1993 end-page: 457 ident: BIB5 article-title: Target dose versus extra-target dose in stereotactic radiosurgery publication-title: Acta Oncol contributor: fullname: Lax – volume: 46 start-page: 329 year: 2000 end-page: 335 ident: BIB3 article-title: Extracranial stereotactic radiation therapy: set-up accuracy of patients treated for liver metastases publication-title: Int J Radiat Oncol Biol Phys contributor: fullname: Lohr – volume: 57 start-page: 225 year: 2000 end-page: 236 ident: BIB17 article-title: Stereotactic radiotherapy of extracranial targets: CT-simulation and accuracy of treatment in the stereotactic body frame publication-title: Radiother Oncol contributor: fullname: Flentje – volume: 51 start-page: 304 year: 2001 end-page: 310 ident: BIB10 article-title: Detection of lung tumor movement in real-time tumor-tracking radiotherapy publication-title: Int J Radiat Oncol Biol Phys contributor: fullname: Ogura – volume: 34 start-page: 861 year: 1995 end-page: 870 ident: BIB1 article-title: Stereotactic high dose fractionation radiation therapy of extracranial tumors using an accelerator publication-title: Acta Oncol contributor: fullname: Svanström – volume: 50 start-page: 367 year: 1999 end-page: 370 ident: BIB9 article-title: Three dimensional movement of a liver tumor detected by high-speed magnetic resonance publication-title: Radiother Oncol contributor: fullname: Xo – volume: 33 start-page: 677 year: 1994 end-page: 683 ident: BIB6 article-title: Stereotactic radiotherapy of malignancies in the abdomen. Methodological aspects publication-title: Acta Oncol contributor: fullname: Svanström – volume: 48 start-page: 449 year: 2000 end-page: 457 ident: BIB8 article-title: Megavoltage CT-assisted stereotactic radiosurgery for thoracic tumors: original research in the treatment of thoracic neoplasms publication-title: Int J Radiat Oncol Biol Phys contributor: fullname: Ohtomo – volume: 1 start-page: 63 year: 1998 end-page: 74 ident: BIB2 article-title: Radiosurgery for tumors in the body: clinical experience using a new method publication-title: J Radiosurg contributor: fullname: Göranson – volume: 37 start-page: 731 year: 1997 end-page: 736 ident: BIB15 article-title: A conformation number to quantify the degree of conformality in brachytherapy and external beam irradiation: application to the prostate publication-title: Int J Radiat Oncol Biol Phys contributor: fullname: Van der Zee – volume: 19 start-page: 164 year: 2001 end-page: 170 ident: BIB4 article-title: Stereotactic single dose radiation therapy of liver tumors: results of a phase I/II trial publication-title: J Clin Oncol contributor: fullname: Lohr – ident: 10.1016/S0167-8140(02)00372-9_BIB11 – volume: 46 start-page: 329 issue: 2 year: 2000 ident: 10.1016/S0167-8140(02)00372-9_BIB3 article-title: Extracranial stereotactic radiation therapy: set-up accuracy of patients treated for liver metastases publication-title: Int J Radiat Oncol Biol Phys doi: 10.1016/S0360-3016(99)00413-7 contributor: fullname: Herfarth – volume: 32 start-page: 453 issue: 4 year: 1993 ident: 10.1016/S0167-8140(02)00372-9_BIB5 article-title: Target dose versus extra-target dose in stereotactic radiosurgery publication-title: Acta Oncol doi: 10.3109/02841869309093624 contributor: fullname: Lax – volume: 50 start-page: 337 year: 1999 ident: 10.1016/S0167-8140(02)00372-9_BIB13 article-title: Daily positioning accuracy of frameless stereotatctic radiation therapy with a fusion of computed tomography and linear accellarator (focal) unit: evaluation of z-axis with a z-marker publication-title: Radiother Oncol doi: 10.1016/S0167-8140(99)00037-7 contributor: fullname: Uematsu – volume: 34 start-page: 861 year: 1995 ident: 10.1016/S0167-8140(02)00372-9_BIB1 article-title: Stereotactic high dose fractionation radiation therapy of extracranial tumors using an accelerator publication-title: Acta Oncol doi: 10.3109/02841869509127197 contributor: fullname: Blomgren – volume: 33 start-page: 677 year: 1994 ident: 10.1016/S0167-8140(02)00372-9_BIB6 article-title: Stereotactic radiotherapy of malignancies in the abdomen. Methodological aspects publication-title: Acta Oncol doi: 10.3109/02841869409121782 contributor: fullname: Lax – volume: 19 start-page: 164 issue: 1 year: 2001 ident: 10.1016/S0167-8140(02)00372-9_BIB4 article-title: Stereotactic single dose radiation therapy of liver tumors: results of a phase I/II trial publication-title: J Clin Oncol doi: 10.1200/JCO.2001.19.1.164 contributor: fullname: Herfarth – volume: 37 start-page: 731 issue: 3 year: 1997 ident: 10.1016/S0167-8140(02)00372-9_BIB15 article-title: A conformation number to quantify the degree of conformality in brachytherapy and external beam irradiation: application to the prostate publication-title: Int J Radiat Oncol Biol Phys doi: 10.1016/S0360-3016(96)00601-3 contributor: fullname: Van't Riet – volume: 1 start-page: 63 issue: 1 year: 1998 ident: 10.1016/S0167-8140(02)00372-9_BIB2 article-title: Radiosurgery for tumors in the body: clinical experience using a new method publication-title: J Radiosurg doi: 10.1023/B:JORA.0000010880.40483.c4 contributor: fullname: Blomgren – volume: 48 start-page: 443 issue: 2 year: 2000 ident: 10.1016/S0167-8140(02)00372-9_BIB14 article-title: Intrafractional tumor position stability during computed tomography (CT)-guided frameless stereotactic radiation therapy for lung or liver cancers with a fusion of CT and linear accelerator (focal) unit publication-title: Int J Radiat Oncol Biol Phys doi: 10.1016/S0360-3016(00)00619-2 contributor: fullname: Uematsu – volume: 57 start-page: 225 year: 2000 ident: 10.1016/S0167-8140(02)00372-9_BIB17 article-title: Stereotactic radiotherapy of extracranial targets: CT-simulation and accuracy of treatment in the stereotactic body frame publication-title: Radiother Oncol doi: 10.1016/S0167-8140(00)00226-7 contributor: fullname: Wulf – volume: 50 start-page: 367 year: 1999 ident: 10.1016/S0167-8140(02)00372-9_BIB9 article-title: Three dimensional movement of a liver tumor detected by high-speed magnetic resonance publication-title: Radiother Oncol doi: 10.1016/S0167-8140(98)00140-6 contributor: fullname: Shimizu – volume: 1 start-page: 135 issue: 2 year: 1998 ident: 10.1016/S0167-8140(02)00372-9_BIB7 article-title: Extracranial stereotactic radiosurgery of localized targets publication-title: J Radiosurg doi: 10.1023/B:JORA.0000010898.87146.2e contributor: fullname: Lax – volume: 51 start-page: 304 issue: 2 year: 2001 ident: 10.1016/S0167-8140(02)00372-9_BIB10 article-title: Detection of lung tumor movement in real-time tumor-tracking radiotherapy publication-title: Int J Radiat Oncol Biol Phys doi: 10.1016/S0360-3016(01)01641-8 contributor: fullname: Shimizu – volume: 48 start-page: 449 issue: 2 year: 2000 ident: 10.1016/S0167-8140(02)00372-9_BIB8 article-title: Megavoltage CT-assisted stereotactic radiosurgery for thoracic tumors: original research in the treatment of thoracic neoplasms publication-title: Int J Radiat Oncol Biol Phys doi: 10.1016/S0360-3016(00)00617-9 contributor: fullname: Nakagawa – volume: 82 start-page: 1062 year: 1998 ident: 10.1016/S0167-8140(02)00372-9_BIB12 article-title: Focal, high dose, and fractionated modified stereotactic radiation therapy for lung carcinoma patients publication-title: Cancer doi: 10.1002/(SICI)1097-0142(19980315)82:6<1062::AID-CNCR8>3.0.CO;2-G contributor: fullname: Uematsu – volume: 44 start-page: 911 issue: 4 year: 1999 ident: 10.1016/S0167-8140(02)00372-9_BIB16 article-title: The use of active breathing control (ABC) to reduce margin for breathing motion publication-title: Int J Radiat Oncol Biol Phys doi: 10.1016/S0360-3016(99)00056-5 contributor: fullname: Wong – volume: 177 start-page: 645 year: 2001 ident: 10.1016/S0167-8140(02)00372-9_BIB18 article-title: Stereotactic radiotherapy of targets in the lung and liver publication-title: Strahlenther Onkol doi: 10.1007/PL00002379 contributor: fullname: Wulf |
SSID | ssj0002037 |
Score | 2.010488 |
Snippet | Background and purpose: Previous analyses of target reproducibility in extracranial stereotactic radiotherapy have revealed standard security margins for... Previous analyses of target reproducibility in extracranial stereotactic radiotherapy have revealed standard security margins for planning target volume (PTV)... |
SourceID | crossref pubmed elsevier |
SourceType | Aggregation Database Index Database Publisher |
StartPage | 141 |
SubjectTerms | Adolescent Adult Aged Computed tomography simulation Conformal radiotherapy Dose-Response Relationship, Radiation Dose–volume histogram Female Humans Liver Neoplasms - radiotherapy Lung Neoplasms - radiotherapy Male Middle Aged Radiotherapy Planning, Computer-Assisted Reproducibility of Results Stereotactic body frame Stereotactic radiotherapy Stereotaxic Techniques Treatment accuracy Treatment Outcome |
Title | Impact of target reproducibility on tumor dose in stereotactic radiotherapy of targets in the lung and liver |
URI | https://dx.doi.org/10.1016/S0167-8140(02)00372-9 https://www.ncbi.nlm.nih.gov/pubmed/12648785 |
Volume | 66 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV09a8MwEBUhhdKl9Ps7aOjQDk5kyZbkMYSGpG1C6QdkM5IsQSC1S-IMWfrbK8kOaadAJ8Mhn82TuDvwe88A3CojM6kpCShSLIgUo4FIlAyMJBEiRuDYm1WPxnTwET1O4kkD9NZaGEerrGt_VdN9ta4jnRrNztd02nlzBHrn14Qcv8rOiE7BbpuRPdPt7w3NA6PKN9P5e7vVGxVPlcEH7xC-90mCZEt_-tV8-gdgv54aYbd6sUPQ0PkR2B3V38WPwWzoxY6wMLCidkNnVum8XCvy6woWOSyXn8UcZsVCw2kOnUGCLkqvkYJzkU1rKdZqk2Th1tkonNmKAEWewZljcZyA9_7De28Q1P9RCFSEWRmIMNQZESaUFHFhmKKSMMNpGArKYyRsABONdcSzhBsimUFCa55ghmIkY3IKmnmR63MAubLzCVJCswxHXCVcSRwbzTnRieQZuwDtNXjpV-WWkf6ikVGWOrRThFOPdppcAL6GOP2z7amt6NtuPau2ZPMkx9ZjPL78f9IrsOfZep6WfQ2a5Xypb-zUUcqWP1YtsNPtvT6_uOvwaTD-AQaZ1BQ |
link.rule.ids | 315,786,790,4521,24144,27957,27958,45620,45714 |
linkProvider | Elsevier |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnZ3PT8MgFMfJnIl6Mf52_uTgQQ_dKLRAj2Zx2XTz4kx2I0AhWTJbM7vDLv7tFtplelri9YU-mgd5vITP-wLAnbYqVYaSgCLNgkgzGshEq8AqEiFiJY69WPXolfbfo-dJPGmA7qoXxmGVde6vcrrP1rWlU0ez8zmddt4cQO_0mpDjq8oacQtsu3Levd_Q_l5zHhhVwplO4NsNX7fxVC688R7hB-8lSDYcUL9On94B2K_LRvhY_dkhaJjsCOyM6ovxYzAb-G5HmFtYsd3QqVU6MdeKfl3CPIPF4iOfwzT_MnCaQaeQYPLCN0nBuUyndS_Wcu3ky40rrXBWpgQosxTOHMZxAsa9p3G3H9QPKQQ6wqwIZBialEgbKoq4tExTRZjlNAwl5TGSpQETg03E04RbophF0hieYIZipGJyCppZnplzALkuCxSkpWEpjrhOuFY4toZzYhLFU9YC7VXwxGcllyF-cWSUCRdtgbDw0RZJC_BViMWfdRdlSt_06Vm1JOuZHK7HeHzxf6e3YLc_Hg3FcPD6cgn2PLrnGe0r0CzmC3NdliCFuvFb7AdzmNQR |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Impact+of+target+reproducibility+on+tumor+dose+in+stereotactic+radiotherapy+of+targets+in+the+lung+and+liver&rft.jtitle=Radiotherapy+and+oncology&rft.au=Wulf%2C+J%C3%B6rn&rft.au=H%C3%A4dinger%2C+Ulrich&rft.au=Oppitz%2C+Ulrich&rft.au=Thiele%2C+Wibke&rft.date=2003-02-01&rft.issn=0167-8140&rft.volume=66&rft.issue=2&rft.spage=141&rft.epage=150&rft_id=info:doi/10.1016%2FS0167-8140%2802%2900372-9&rft.externalDBID=n%2Fa&rft.externalDocID=10_1016_S0167_8140_02_00372_9 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0167-8140&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0167-8140&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0167-8140&client=summon |