Impact of target reproducibility on tumor dose in stereotactic radiotherapy of targets in the lung and liver

• Published in: Radiotherapy and oncology Vol. 66; no. 2; pp. 141 - 150
• Main Authors: Wulf, Jörn, Hädinger, Ulrich, Oppitz, Ulrich, Thiele, Wibke, Flentje, Michael
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier Ireland Ltd 01.02.2003
• Subjects: Adolescent; Adult; Aged; Computed tomography simulation; Conformal radiotherapy; Dose-Response Relationship, Radiation; Dose–volume histogram; Female; Humans; Liver Neoplasms - radiotherapy; Lung Neoplasms - radiotherapy; Male; Middle Aged; Radiotherapy Planning, Computer-Assisted; Reproducibility of Results; Stereotactic body frame; Stereotactic radiotherapy; Stereotaxic Techniques; Treatment accuracy; Treatment Outcome; Conformal radiotherapy; Stereotactic body frame; Computed tomography simulation; Treatment accuracy; Stereotactic radiotherapy; Dose–volume histogram
• ISSN: 0167-8140; 1879-0887
• DOI: 10.1016/S0167-8140(02)00372-9

Background and purpose: Previous analyses of target reproducibility in extracranial stereotactic radiotherapy have revealed standard security margins for planning target volume (PTV) definition of 5 mm in axial and 5–10 mm in longitudinal direction. In this study the reproducibility of the clinical target volume (CTV) of lung and liver tumors within the PTV over the complete course of hypofractionated treatment is evaluated. The impact of target mobility on dose to the CTV is assessed by dose–volume histograms (DVH). Materials and methods: Twenty-two pulmonary and 21 hepatic targets were treated with three stereotactic fractions of 10 Gy to the PTV-enclosing 100%-isodose with normalization to 150% at the isocenter. A conformal dose distribution was related to the PTV, which was defined by margins of 5–10 mm added to the CTV. Prior to each fraction a computed tomography (CT)-simulation over the complete target volume was performed resulting in a total of 60 CT-simulations for lung and 58 CT-simulations for hepatic targets. The CTV from each CT-simulation was segmented and matched with the CT-study used for treatment planning. A DVH of the simulated CTV was calculated for each fraction. The target coverage (TC) of dose to the simulated CTV was defined as the proportion of the CTV receiving at least the reference dose (100%). Results: A decrease of TC to <95% was found in 3/60 simulations (5%) of pulmonary and 7/58 simulations (12%) of hepatic targets. In two of 22 pulmonary targets (9%) and in four of 21 hepatic targets (19%) a TC of <95% occurred in at least one fraction. At risk for a decreased TC <95% were pulmonary targets with increased breathing mobility and hepatic targets with a CTV exceeding 100 cm 3. Conclusions: Target reproducibility was precise within the reference isodose in 91% of lung and 81% of liver tumors with a TC of the complete CTV ≥95% at each fraction of treatment. Pulmonary targets with increased breathing mobility and liver tumors >100 cm 3 are at risk for target deviation exceeding the standard security margins for PTV-definition at least for one fraction and require individual evaluation of sufficient margins.