Neurotrophins as synaptic modulators

The role of neurotrophins as regulatory factors that mediate the differentiation and survival of neurons has been well described. More recent evidence indicates that neurotrophins may also act as synaptic modulators. Here, I review the evidence that synaptic activity regulates the synthesis, secreti...

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Bibliographic Details
Published inNature reviews. Neuroscience Vol. 2; no. 1; pp. 24 - 32
Main Author Poo, Mu-ming
Format Journal Article
LanguageEnglish
Published England Nature Publishing Group 01.01.2001
Subjects
Animals
Brain-derived neurotrophic factor
Humans
Kinases
Nerve Growth Factors - physiology
Neuronal Plasticity
Neurons
Neurons - cytology
Neurons - physiology
Protein synthesis
Proteins
Synapses - physiology
Synaptic Transmission - physiology
United States > US
California
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Summary:The role of neurotrophins as regulatory factors that mediate the differentiation and survival of neurons has been well described. More recent evidence indicates that neurotrophins may also act as synaptic modulators. Here, I review the evidence that synaptic activity regulates the synthesis, secretion and action of neurotrophins, which can in turn induce immediate changes in synaptic efficacy and morphology. By this account, neurotrophins may participate in activity-dependent synaptic plasticity, linking synaptic activity with long-term functional and structural modification of synaptic connections.
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ISSN:1471-003X
1471-0048
1471-0048
1469-3178
DOI:10.1038/35049004