Monitoring heavy metals, residual agricultural chemicals and sulfites in traditional herbal decoctions

• Published in: BMC complementary and alternative medicine Vol. 17; no. 1; p. 154
• Main Authors: Yu, In-Sil, Lee, Jeong-Sook, Kim, Sung-Dan, Kim, Yun-Hee, Park, Hae-Won, Ryu, Hoe-Jin, Lee, Jib-Ho, Lee, Jeong-Mi, Jung, Kweon, Na, Cheol, Joung, Jin-Yong, Son, Chang-Gue
• Format: Journal Article
• Language: English
• Published: England BioMed Central 14.03.2017
• Subjects: Agrochemicals; Agrochemicals - analysis; Arsenic; Beta decay; Cadmium; Chemicals; Chinese medicine; Drug Contamination - statistics & numerical data; Drug dosages; Electron capture; Food contamination; Food contamination & poisoning; Gas chromatography; Gas flow; Ginseng; Hazardous materials; Heavy metals; Herbal medicine; Herbs; Inductively coupled plasma mass spectrometry; Lead; Mass Spectrometry; Mass spectroscopy; Mercury; Mercury (metal); Metal concentrations; Metals, Heavy - analysis; Pesticide Residues - analysis; Pesticides; Plant Extracts - analysis; Plants, Medicinal - chemistry; Quality control; Quality standards; Republic of Korea; Sulfites; Sulfites - analysis; Sulfur; Sulfur dioxide; East Asia; United States > US; China; Japan; Herbal decoction; Contamination; Heavy metals; Sulfur dioxide; Pesticides; Quality control
• ISSN: 1472-6882; 1472-6882
• DOI: 10.1186/s12906-017-1646-y

Asian traditional herbal preparations are frequently considered for the contamination with undeclared toxic or hazardous substances. The aim of this study was to determine the toxic heavy metals, pesticides and sulfur dioxide in decoctions that is a common form of final utilization in Korea. A total of 155 decoctions composed of multi-ingredient traditional herbs were randomly sampled from Seoul in Korea between 2013 and 2014. For each decoction, the concentrations of four heavy metals (arsenic, cadmium, lead and mercury), 33 pesticides and sulfur dioxide were analyzed using inductively coupled plasma mass spectrometry (ICP-MS), mercury analyzer, gas chromatography/nitrogen phosphorous detector (GC/NPD), gas chromatography/micro electron capture detector (GC/μECD), and Monier-Williams method respectively. One hundred fifty-two of One hundred fifty-five decoctions (98.1%) contained one of three heavy metals (96.1% for As, 97.4% for Cd, and 90.3% for Pb, 0.0% for Hg). Their average concentrations (77.0 ± 79.7 ug/kg for As, 20.4 ± 23.7 ug/kg for Cd, and 68.8 ± 76.5 ug/kg for Pb) were approximately 20% of the maximum allowable limits of vegetable or ginseng beverage described in the Korean Food Standard Codex while their 95th percentile concentrations were below than the guideline for them. None of 33 pesticides was detected in 155 decoction samples, and only one sample showed over limit of detection for residual sulfites. This study support that the contained status of toxic heavy metals, pesticides and sulfur dioxide in herbal decoctions are currently within safe level in Korea, and provide a reference data for the further studies focused on the safety herbal preparations.