The Effects of Fatty Acids on Primary Liver Cancer: A Two-Sample Mendelian Randomization Study

Currently, it is unknown whether fatty acids (FAs) and primary liver cancer (PLC) are associated. The cause-effect association was established using a two-sample Mendelian randomization (MR) study. Eligible single nucleotide polymorphisms were selected as instrumental variables from six FAs genome-w...

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Bibliographic Details
Published inNutrition and cancer Vol. 75; no. 7; pp. 1560 - 1570
Main Authors Liu, Yuan, He, Jian, Cai, Longjiao, Leng, Aimin
Format Journal Article
LanguageEnglish
Published United States Taylor & Francis 09.08.2023
Taylor & Francis Ltd
Subjects
Biomarkers
Causality
confidence interval
Fatty acids
Genome-wide association studies
Genomes
Health hazards
Liver
Liver cancer
liver neoplasms
Nucleotides
nutrition
Pleiotropy
Preventive medicine
Randomization
Risk reduction
Sensitivity analysis
Single-nucleotide polymorphism
Stability analysis
standard deviation
variance
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Summary:Currently, it is unknown whether fatty acids (FAs) and primary liver cancer (PLC) are associated. The cause-effect association was established using a two-sample Mendelian randomization (MR) study. Eligible single nucleotide polymorphisms were selected as instrumental variables from six FAs genome-wide association studies. The outcome involved a total of 260,428 subjects and was a summary of genetic data on PLC from FinnGen biobanks. The principal method inverse variance weighted (IVW) and several other analytical approaches (MR-Egger, Weighted Median, and Maximum likelihood) were tested to determine the causal relationship between different FAs and PLC. Furthermore, sensitivity analyses were performed to determine the stability of the results. The two-sample MR analysis revealed a negative causal relationship between omega-3 FAs and PLC. It was discovered that an increase in each standard deviation (0.53 mmol/L; SD: 0.22) in the genetic levels of omega-3 FAs reduced the risk of PLC by 62.1% through the IVW method [odd ratio: 0.379; 95% confidence interval (0.176, 0.816)]. Nevertheless, other FAs were not statistically correlated with PLC. Additionally, no pleiotropy was found between the two. According to the MR study, consuming omega-3 FAs may help prevent PLC.
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ISSN:0163-5581
1532-7914
1532-7914
DOI:10.1080/01635581.2023.2216914