Pharmacokinetics and bioavailability of doxycycline hyclate after oral administration in calves

• Published in: The Veterinary quarterly Vol. 15; no. 1; p. 1
• Main Authors: Meijer, L.A. (Dopharma Research BV, Raamsdonkveer (Netherlands)), Ceyssens, K.G.F, Greve, B.I.J.A.C. de, Bruijn, W. de
• Format: Journal Article
• Language: English
• Published: England 01.03.1993
• Subjects: Administration, Oral; Animals; ANTIMICROBIALS; ANTIMICROBIANO; ANTIMICROBIEN; Biological Availability; CALVES; Cattle - metabolism; DISPONIBILIDAD DE NUTRIENTES; Doxycycline - administration & dosage; Doxycycline - analogs & derivatives; Doxycycline - pharmacokinetics; ELEMENT NUTRITIF DISPONIBLE; FARMACOLOGIA; Half-Life; Injections, Intravenous - veterinary; Male; NUTRIENT AVAILABILITY; Pharmaceutical Vehicles; PHARMACOLOGIE; PHARMACOLOGY; Rumen - physiology; TERNERO; VEAU

The bioavailability and pharmacokinetics of doxycycline hyclate were determined in calves with immature rumen function. The bioavailability of doxycycline after oral administration in a milk replacer was approximately 70%. The elimination half-life of doxycycline was found to be 9.5 +/- 3.0 h. after...