Pharmacokinetics and bioavailability of doxycycline hyclate after oral administration in calves

The bioavailability and pharmacokinetics of doxycycline hyclate were determined in calves with immature rumen function. The bioavailability of doxycycline after oral administration in a milk replacer was approximately 70%. The elimination half-life of doxycycline was found to be 9.5 +/- 3.0 h. after...

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Bibliographic Details
Published inThe Veterinary quarterly Vol. 15; no. 1; p. 1
Main Authors Meijer, L.A. (Dopharma Research BV, Raamsdonkveer (Netherlands)), Ceyssens, K.G.F, Greve, B.I.J.A.C. de, Bruijn, W. de
Format Journal Article
LanguageEnglish
Published England 01.03.1993
Subjects
Administration, Oral
Animals
ANTIMICROBIALS
ANTIMICROBIANO
ANTIMICROBIEN
Biological Availability
CALVES
Cattle - metabolism
DISPONIBILIDAD DE NUTRIENTES
Doxycycline - administration & dosage
Doxycycline - analogs & derivatives
Doxycycline - pharmacokinetics
ELEMENT NUTRITIF DISPONIBLE
FARMACOLOGIA
Half-Life
Injections, Intravenous - veterinary
Male
NUTRIENT AVAILABILITY
Pharmaceutical Vehicles
PHARMACOLOGIE
PHARMACOLOGY
Rumen - physiology
TERNERO
VEAU
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Summary:The bioavailability and pharmacokinetics of doxycycline hyclate were determined in calves with immature rumen function. The bioavailability of doxycycline after oral administration in a milk replacer was approximately 70%. The elimination half-life of doxycycline was found to be 9.5 +/- 3.0 h. after intravenous administration, and 12.6 +/- 5.0 h. after single oral administration. Plasma concentrations were determined after repeated oral administration of doxycycline dissolved in a milk replacer, at a dose of 5 mg per kg body weight, twice daily. During the period of administration, the plasma concentrations varied between Cmin of 1.0 +/- 0.19 mg/L and Cmax of 2.3 +/- 0.19 mg/L.
Bibliography:9302783
L73
ISSN:0165-2176
1875-5941
DOI:10.1080/01652176.1993.9694358