PennPET Explorer: Human Imaging on a Whole-Body Imager

• Published in: Journal of Nuclear Medicine Vol. 61; no. 1; pp. 144 - 151
• Main Authors: Pantel, Austin R., Viswanath, Varsha, Daube-Witherspoon, Margaret E., Dubroff, Jacob G., Muehllehner, Gerd, Parma, Michael J., Pryma, Daniel A., Schubert, Erin K., Mankoff, David A., Karp, Joel S.
• Format: Journal Article
• Language: English
• Published: United States Society of Nuclear Medicine 01.01.2020
• Subjects: Adult; Aged; Diagnostic systems; Experimental research; Female; Field of view; Fluorine isotopes; Fluorodeoxyglucose F18 - chemistry; Healthy Volunteers; Humans; Image Processing, Computer-Assisted - methods; Image quality; Kinetics; Male; Medical imaging; Middle Aged; Organometallic Compounds - chemistry; Organs; Phantoms, Imaging; Physics and Instrumentation; Positron emission; Positron emission tomography; Positron-Emission Tomography - instrumentation; Positron-Emission Tomography - methods; Radioactive tracers; Scanners; Sensitivity; Tomography; Whole Body Imaging - instrumentation; Whole Body Imaging - methods; PET; human imaging; whole-body imager
• ISSN: 0161-5505; 1535-5667; 2159-662X; 1535-5667
• DOI: 10.2967/jnumed.119.231845

The PennPET Explorer, a prototype whole-body imager currently operating with a 64-cm axial field of view, can image the major body organs simultaneously with higher sensitivity than that of commercial devices. We report here the initial human imaging studies on the PennPET Explorer, with each study designed to test specific capabilities of the device. Healthy subjects were imaged with FDG on the PennPET Explorer. Subsequently, clinical subjects with disease were imaged with F-FDG and Ga-DOTATATE, and research subjects were imaged with experimental radiotracers. We demonstrated the ability to scan for a shorter duration or, alternatively, with less activity, without a compromise in image quality. Delayed images, up to 10 half-lives with F-FDG, revealed biologic insight and supported the ability to track biologic processes over time. In a clinical subject, the PennPET Explorer better delineated the extent of F-FDG-avid disease. In a second clinical study with Ga-DOTATATE, we demonstrated comparable diagnostic image quality between the PennPET scan and the clinical scan, but with one fifth the activity. Dynamic imaging studies captured relatively noise-free input functions for kinetic modeling approaches. Additional studies with experimental research radiotracers illustrated the benefits from the combination of large axial coverage and high sensitivity. These studies provided a proof of concept for many proposed applications for a PET scanner with a long axial field of view.