An inherited limb deformity created by insertional mutagenesis in a transgenic mouse

We have created an insertional mutation that leads to a severe defect in the pattern of limb formation in the developing mouse. The novel recessive mutation is phenotypically identical and non-complementary to two previously encountered limb deformity mutations, and is closely linked to a dominant m...

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Bibliographic Details
Published inNature (London) Vol. 318; no. 6041; p. 36
Main Authors Woychik, R P, Stewart, T A, Davis, L G, D'Eustachio, P, Leder, P
Format Journal Article
LanguageEnglish
Published England 01.11.1985
Subjects
Animals
Chromosome Mapping
Cloning, Molecular
Extremities - embryology
Genes, Recessive
Genetic Complementation Test
Mammary Tumor Virus, Mouse - genetics
Mice - embryology
Mice - genetics
Mutation
Pedigree
Phenotype
Proto-Oncogenes
Transformation, Genetic
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Summary:We have created an insertional mutation that leads to a severe defect in the pattern of limb formation in the developing mouse. The novel recessive mutation is phenotypically identical and non-complementary to two previously encountered limb deformity mutations, and is closely linked to a dominant mutation that gives rise to a related limb dysmorphism. The inserted element thus provides a molecular genetic link with the control of pattern formation in the mammalian embryo.
ISSN:0028-0836
1476-4687
DOI:10.1038/318036a0