Antidiabetic effect of Gymnema montanum leaves: effect on lipid peroxidation induced oxidative stress in experimental diabetes
Gymnema montanum is widely used in ancient medicine for the ailment of various diseases. Oral administration of 200 mg kg −1 (body weight) BW of the alcoholic extract of the leaf for 3 weeks resulted in a significant reduction in blood glucose and an increase in plasma insulin, whereas the effect of...
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Published in | Pharmacological research Vol. 48; no. 6; pp. 551 - 556 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
Netherlands
Elsevier Ltd
01.12.2003
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Subjects | |
Online Access | Get full text |
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Summary: | Gymnema montanum is widely used in ancient medicine for the ailment of various diseases. Oral administration of 200
mg
kg
−1 (body weight) BW of the alcoholic extract of the leaf for 3 weeks resulted in a significant reduction in blood glucose and an increase in plasma insulin, whereas the effect of 50 and 100
mg
kg
−1 BW was not significant. The alcoholic extract also resulted in decreased free radical formation in plasma of diabetic rats. Thus, this study shows that
Gymnema montanum leaf extract (GLEt) possess antihyperglycemic and antiperoxidative effect. The decrease in lipid peroxides and increase in reduced glutathione (GSH), ascorbic acid (Vitamin C) and α-tocopherol (Vitamin E) clearly show the antioxidant properties of GLEt. The effect of GLEt was most prominently seen in the case of animals given 200
mg
kg
−1 BW. In addition, the results suggest that GLEt was highly effective than the reference drug glibenclamide. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 1043-6618 1096-1186 |
DOI: | 10.1016/S1043-6618(03)00219-6 |