Enantiomer separation of chiral pharmaceuticals by capillary electrochromatography

Enantiomer separation of chiral pharmaceuticals by capillary electrochromatography (CEC) is achieved with open-tubular capillaries (o-CEC), with packed capillaries (p-CEC) or with monolithic capillaries. In o-CEC, capillaries are coated with a thin film containing cyclodextrin derivatives, cellulose...

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Published inJournal of Chromatography A Vol. 875; no. 1; pp. 255 - 276
Main Authors Wistuba, Dorothee, Schurig, Volker
Format Book Review Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 14.04.2000
Subjects
Antibiotics
Chromatography, Micellar Electrokinetic Capillary - methods
Glycoproteins
Peptides
Pharmaceutical Preparations - chemistry
Pharmaceutical Preparations - isolation & purification
Proteins
Saccharides
Stereoisomerism
Proteins
Reviews
Peptides
Antibiotics
Enantiomer separation
Electrochromatography
Glycoproteins
Pharmaceutical analysis
Molecular imprinting
Saccharides
Chiral selectors
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Summary:Enantiomer separation of chiral pharmaceuticals by capillary electrochromatography (CEC) is achieved with open-tubular capillaries (o-CEC), with packed capillaries (p-CEC) or with monolithic capillaries. In o-CEC, capillaries are coated with a thin film containing cyclodextrin derivatives, cellulose, proteins, poly-terguride or molecularly imprinted polymers as chiral selectors. In p-CEC, typical chiral HPLC stationary phases such as silica-bonded cyclodextrin or cellulose derivatives, proteins, glycoproteins, macrocyclic antibiotics, quinine-derived and ‘Pirkle’ selectors, polyacrylamides and molecularly imprinted polymers are used as chiral selectors. Chiral monolithic stationary phases prepared by in situ polymerization into the capillary were also developed for electrochromatographic enantiomer separation.
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ISSN:0021-9673
DOI:10.1016/S0021-9673(00)00066-2