Bioactivity-Guided Isolation and Identification of New and Immunosuppressive Monoterpenoid Indole Alkaloids from Rauvolfia yunnanensis Tsiang

Three new 11-hydroxyburnamine ( ) and rauvoyunnanines A-B ( - ), and fourteen known ( - ) monoterpenoid indole alkaloids were isolated from the total alkaloids extract of , which exhibited promising immunosuppressive activity on T cell proliferation in preliminary screening. Their structures were de...

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Published inMolecules (Basel, Switzerland) Vol. 24; no. 24; p. 4574
Main Authors Li, Li-Mei, Shi, Shun-Dong, Liu, Yang, Zou, Qiang
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 13.12.2019
MDPI
Subjects
Absorption spectra
Acids
Ajmalicine
Alkaloids
Autoimmune diseases
Biological activity
Carbon
Cell growth
Cell proliferation
Cell Proliferation - drug effects
Cells, Cultured
Chromatography
Experiments
Herbal medicine
Humans
Immunosuppressive agents
Immunosuppressive Agents - chemistry
Immunosuppressive Agents - pharmacology
Indoles
Inhibitory Concentration 50
Lymphocytes
Lymphocytes T
Medicinal plants
Molecular Structure
NMR
Nuclear magnetic resonance
Rauwolfia - chemistry
Reserpine
Reserpine - chemistry
Reserpine - pharmacology
Secologanin Tryptamine Alkaloids - chemistry
Secologanin Tryptamine Alkaloids - pharmacology
T-Lymphocytes - cytology
T-Lymphocytes - drug effects
Yohimbine
United States > US
China
Japan
Germany
monoterpenoid indole alkaloid
11-hydroxyburnamine
immunosuppressive activity
rauvoyunnanine B
rauvoyunnanine A
Rauvolfia yunnanensis
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Summary:Three new 11-hydroxyburnamine ( ) and rauvoyunnanines A-B ( - ), and fourteen known ( - ) monoterpenoid indole alkaloids were isolated from the total alkaloids extract of , which exhibited promising immunosuppressive activity on T cell proliferation in preliminary screening. Their structures were determined by analysis of high-resolution electrospray ionization mass (HRESIMS), ultraviolet (UV) and nuclear magnetic resonance (NMR) data, and by comparison with the literature. All the alkaloids were evaluated for inhibitory activity on T cell proliferation. Among them, one new compound ( ) and reserpine ( ) exhibited moderate immunosuppressive activity, with IC values of 5.9 μM and 5.0 μM, respectively.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules24244574