Changes of myelinated nerve and myelin basic protein expression in rats' periodontal ligaments after experimental tooth movement

• Published in: American journal of orthodontics and dentofacial orthopedics Vol. 142; no. 6; pp. 814 - 824
• Main Authors: Lu, Lei, Huang, Jing-Hui, Yu, Shi-Bin, Liu, Xiao-Dong, Zhang, Yuan, Zhang, Xu, Qiu, Zhong-Ying, Wang, Mei-Qing
• Format: Journal Article
• Language: English
• Published: New York, NY Mosby, Inc 01.12.2012; Elsevier
• Subjects: Animals; Biological and medical sciences; Dentistry; Medical sciences; Mitochondria - pathology; Myelin Basic Protein - biosynthesis; Nerve Degeneration; Nerve Fibers, Myelinated - physiology; Otorhinolaryngology. Stomatology; Periodontal Ligament - innervation; Rats; Tooth Movement Techniques; Vertebrata; Periodontal ligament; Orthodontic procedures; Mammalia; Rat; Animal; Rodentia; Teeth; Tooth; Dentistry; Protein
• ISSN: 0889-5406; 1097-6752
• DOI: 10.1016/j.ajodo.2012.08.014

Introduction Information about the effect of tooth movement on the myelinated nerve in the periodontal ligament is limited. In this study, we aimed to investigate what responses of the periodontal myelinated nerve can be evoked during experimental tooth movement. Methods In experimental-I group, the maxillary left and mandibular right third molars were moved distally. In experimental-II group, the maxillary left third molar but not the right one was moved, and the bilateral mandibular third molars were extracted. The ultrastructures of the myelinated nerve in the periodontal ligament of the bilateral maxillary third molars were observed under a transmission electron microscope. The expression of myelin basic protein was evaluated by immunohistochemistry. Results Degenerative ultrastructural changes of the myelinated nerve in the periodontal ligament were noticed mainly in the myelin sheath; these were observed earlier and were recoverable in the experimental-I group. In contrast, the ultrastructural changes of the myelinated nerve occurred mainly in the axons, were observed later, and were unrecoverable in the experimental-II group. A concomitant decrease of myelin basic protein expression was observed in both groups. Conclusions Both experimental tooth movement and occlusal changes accompanying it caused changes of the myelinated nerve in the periodontal ligament.