A new androstanoid metabolite from a soil fungus Curvularia borreriae strain HS-FG-237

A new androstanoid metabolite, 4α-methyl-9α-methoxyandrosta-8,15-diene-3,17-dione (1), was isolated from a soil fungus Curvularia borreriae (Pleosporaceae) strain HS-FG-237. Its structure was determined by extensive spectroscopic and X-ray diffraction analyses. Compound 1 exhibited poor cytotoxicity...

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Bibliographic Details
Published inNatural product research Vol. 31; no. 9; pp. 1080 - 1084
Main Authors Liu, Li-Fei, Zhang, Hui, Qi, Huan, Wang, Xiao-Ming, Wang, Ji-Dong, Tan, Gui-Shan
Format Journal Article
LanguageEnglish
Published England Taylor & Francis 03.05.2017
Taylor & Francis Ltd
Subjects
Androstanes - chemistry
Androstanes - isolation & purification
Androstanes - pharmacology
Androstanoid
Animals
anti-inflammatory activity
Anti-inflammatory agents
Anti-Inflammatory Agents - pharmacology
Antineoplastic Agents - pharmacology
Ascomycota - metabolism
Cholecystokinin
Curvularia
Curvularia borreriae HS-FG-237
cytotoxic activity
Cytotoxicity
Fermentation
Fungi
HCT116 Cells
Humans
Inflammation
Macrophages
Pleosporaceae
Soil Microbiology
Soils
Spectroscopic analysis
Toxicity
X-ray crystallography
X-ray diffraction
X-ray crystallography
cytotoxic activity
Androstanoid
Curvularia borreriae HS-FG-237
anti-inflammatory activity
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Summary:A new androstanoid metabolite, 4α-methyl-9α-methoxyandrosta-8,15-diene-3,17-dione (1), was isolated from a soil fungus Curvularia borreriae (Pleosporaceae) strain HS-FG-237. Its structure was determined by extensive spectroscopic and X-ray diffraction analyses. Compound 1 exhibited poor cytotoxicity toward HCT-116 cells by CCK-8 assay and weak anti-inflammatory activity in an ANA-1 murine macrophages model.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2016.1272115