High levels of urinary midkine in various cancer patients

Midkine (MK) is a heparin-binding growth factor, which promotes growth, migration, and survival of various cells, and MK expression is increased in many human carcinomas. We determined the urinary MK level by enzyme-linked immunoassay. Taking 311 pg/mg creatinine as a cut-off level, 70% of patients...

Full description

Saved in:
Bibliographic Details
Published inBiochemical and biophysical research communications Vol. 306; no. 2; pp. 329 - 332
Main Authors Ikematsu, Shinya, Okamoto, Kohji, Yoshida, Yoshihiro, Oda, Munehiro, Sugano-Nagano, Hitomi, Ashida, Kinya, Kumai, Hideshi, Kadomatsu, Kenji, Muramatsu, Hisako, Takashi Muramatsu, Sakuma, Sadatoshi
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 27.06.2003
Subjects
Adult
Age Factors
Aged
Biomarkers, Tumor
Blotting, Western
Carcinoma - urine
Carrier Proteins - urine
Case-Control Studies
Creatinine - urine
Cytokines
Disease Progression
Enzyme-linked immunoassay
Enzyme-Linked Immunosorbent Assay
Female
Humans
Male
Middle Aged
Midkine
Neoplasms - diagnosis
Neoplasms - urine
Time Factors
Tumor marker
Urine
Tumor marker
Urine
Enzyme-linked immunoassay
Midkine
Online AccessGet full text

Cover

More Information
Summary:Midkine (MK) is a heparin-binding growth factor, which promotes growth, migration, and survival of various cells, and MK expression is increased in many human carcinomas. We determined the urinary MK level by enzyme-linked immunoassay. Taking 311 pg/mg creatinine as a cut-off level, 70% of patients with various carcinomas ( n=142) gave positive values, while only 5.5% of healthy volunteers ( n=330) did. In case of gastric carcinoma, 17 out of 21 patients with stage 1 tumor were positive. Urinary MK levels are expected to become a convenient marker as an aid in detection of tumors.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0006-291X
1090-2104
DOI:10.1016/S0006-291X(03)00984-7