Anti-neuroinflammatory sesquiterpenoids from Chloranthus henryi

• Published in: Natural product research Vol. 37; no. 6; pp. 882 - 890
• Main Authors: Wang, Xue-Jiao, Xin, Jun-Li, Yu, Sheng-Zhou, Pan, Li-Long, Hu, Jin-Feng, Xiong, Juan
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 19.03.2023; Taylor & Francis Ltd
• Subjects: Animals; anti-neuroinflammation; Chloranthaceae; Chloranthus; Chloranthus henryi; Circular dichroism; circular dichroism spectroscopy; Dichroism; Dimers; Enantiomers; Inflammation; Lipopolysaccharides; Magnoliopsida - chemistry; Mice; Microglia; Molecular Structure; Nitric Oxide; Sesquiterpenes - chemistry; Sesquiterpenes - pharmacology; Sesquiterpenoids; Chloranthaceae; Chloranthus henryi; sesquiterpenoids; anti-neuroinflammation
• ISSN: 1478-6419; 1478-6427; 1478-6427
• DOI: 10.1080/14786419.2022.2095633

Hupelactones A (1) and B (2), two new eudesmanolide-type enantiomers of the corresponding compounds, along with four mono- (3-6) and nine dimeric- (7-15) known sesquiterpenoids were isolated from the whole plant of Chloranthus henryi var. hupehensis (syn. C. henryi). The new structures including the absolute configurations were determined by comparison with previously reported enantiomers, extensive spectroscopic methods in combination with electronic circular dichroism (ECD) calculations. All the isolates were evaluated for their inhibitory activities against the lipopolysaccharide (LPS)-induced nitric oxide (NO) production in murine BV-2 microglial cells. Among them, the dimeric lindenane sesquiterpenoids shizukaols F (8) and G (11) exhibited the most potent activities, with IC 50 values of 2.65 and 4.60 μM, respectively.