Sulforaphane Impact on Reactive Oxygen Species (ROS) in Bladder Carcinoma

Sulforaphane (SFN) is a natural glucosinolate found in cruciferous vegetables that acts as a chemopreventive agent, but its mechanism of action is not clear. Due to antioxidative mechanisms being thought central in preventing cancer progression, SFN could play a role in oxidative processes. Since re...

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Published inInternational journal of molecular sciences Vol. 22; no. 11; p. 5938
Main Authors Xie, Hui, Chun, Felix K.-H., Rutz, Jochen, Blaheta, Roman A.
Format Journal Article
LanguageEnglish
Published MDPI 31.05.2021
MDPI AG
Subjects
bladder cancer
Keap1-Nrf2
oxidative stress
Review
ROS
sulforaphane
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Summary:Sulforaphane (SFN) is a natural glucosinolate found in cruciferous vegetables that acts as a chemopreventive agent, but its mechanism of action is not clear. Due to antioxidative mechanisms being thought central in preventing cancer progression, SFN could play a role in oxidative processes. Since redox imbalance with increased levels of reactive oxygen species (ROS) is involved in the initiation and progression of bladder cancer, this mechanism might be involved when chemoresistance occurs. This review summarizes current understanding regarding the influence of SFN on ROS and ROS-related pathways and appraises a possible role of SFN in bladder cancer treatment.
Bibliography:ObjectType-Article-2
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ObjectType-Review-1
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms22115938