Myosin VI: How Do Charged Tails Exert Control?

Molecular dynamics simulations and single molecule experiments are used to suggest that charged helices in the medial tail domain participate in myosin VI dimerization ( Kim et al., 2010), which reinforces the mechanism that unfolding of the three helix bundle in the proximal tail serves as a lever...

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Bibliographic Details
Published inStructure (London) Vol. 18; no. 11; pp. 1393 - 1394
Main Authors Thirumalai, D., Zhang, Zhechun
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 10.11.2010
Subjects
Bundling
Charging
Helices
Levers
Molecular dynamics
Molecular structure
Myosin
Simulation
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Summary:Molecular dynamics simulations and single molecule experiments are used to suggest that charged helices in the medial tail domain participate in myosin VI dimerization ( Kim et al., 2010), which reinforces the mechanism that unfolding of the three helix bundle in the proximal tail serves as a lever arm extension.
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ISSN:0969-2126
1878-4186
DOI:10.1016/j.str.2010.10.004