Effect of two high-oleic oils on the liver lipid composition of spontaneously hypertensive rats

• Published in: Life sciences (1973) Vol. 66; no. 6; pp. 521 - 531
• Main Authors: Perona, Javier S., Ruiz-Gutiérrez, Valentina
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 01.01.2000
• Subjects: Animals; high-oleic sunflower oil; Hypertension - metabolism; Lipids - analysis; Liver - chemistry; Olive Oil; Plant Oils - pharmacology; Rats; Rats, Inbred SHR; spontaneously hypertensive rat; Sunflower Oil; triacylglycerol; Triglycerides - analysis; high-oleic sunflower oil; olive oil; spontaneously hypertensive rat; triacylglycerol
• ISSN: 0024-3205; 1879-0631
• DOI: 10.1016/S0024-3205(99)00622-0

Despite having similar fatty acid composition and plasma lipid composition after ingestion, olive oil, but not high-oleic sunflower oil (HOSO), is capable of reducing blood pressure. HOSO contains mainly triolein, whereas olive oil contains important amounts of dioleoyl-palmitoyl-glycerol. In order to see if its different triacylglycerol (TAG) composition could be related to the hypotensive effect of olive oil, Spontaneously Hypertensive Rats (SHR) were fed with HOSO and olive oil-rich diets. Liver lipid composition was determined. Total lipid, fatty acid and TAG composition was analyzed. Rats fed olive oil (67.24 ± 4.23) were observed to retain more dioleoyl-acyl-glycerol species in their liver than those fed HOSO (56.6 ±3.95), specially triolein (20.69 ± 1.77 olive oil, vs. 12.54 ± 1.97 HOSO), in spite of its lower content of this TAG. On the contrary, rats consuming HOSO had higher amounts of dilinoleoyl-acyl-glycerol species (9.26 ± 1.57 HOSO, vs.4.02 ± 0.90 olive oil). In conclusion, olive oil provided a more beneficial TAG profile in the liver of SHR rats than HOSO, probably due to the differences in the TAG composition of both oils.