Multifloroside Suppressing Proliferation and Colony Formation, Inducing S Cell Cycle Arrest, ROS Production, and Increasing MMP in Human Epidermoid Carcinoma Cell Lines A431
Multifloroside ( ), together with 10-hydroxyoleoside 11-methyl ester ( ), 10-hydroxyoleoside dimethyl ester ( ), and 10-hydroxyligustroside ( ), are all secoiridoids, which are naturally occurring compounds that possess a wide range of biological and pharmacological activities. However, the anti-can...
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Published in | Molecules (Basel, Switzerland) Vol. 25; no. 1; p. 7 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Switzerland
MDPI AG
18.12.2019
MDPI |
Subjects | |
Online Access | Get full text |
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Summary: | Multifloroside (
), together with 10-hydroxyoleoside 11-methyl ester (
), 10-hydroxyoleoside dimethyl ester (
), and 10-hydroxyligustroside (
), are all secoiridoids, which are naturally occurring compounds that possess a wide range of biological and pharmacological activities. However, the anti-cancer activity of
-
has not been evaluated yet. The objective of this work was to study the anti-cancer activities of
-
in the human epidermoid carcinoma cell lines A431 and the human non-small cell lung cancer (NSCLC) cell lines A549. The results indicate that
-
differ in potency in their ability to inhibit the proliferation of human A431 and A549 cells, and multifloroside (
) display the highest inhibitory activity against A431 cells. The structure-activity relationships suggest that the
-hydroxy-
-hydroxy-phenylethyl group may contribute to the anti-cancer activity against A431 cells. Multifloroside treatment can also inhibit cell colony formation, arrest the cell cycle in the S-phase, increase the levels of reactive-oxygen-species (ROS), and mitochondrial membrane potential (MMP), but it did not significantly induce cell apoptosis at low concentrations. The findings indicated that multifloroside (
) has the tendency to show selective anti-cancer effects in A431 cells, along with suppressing the colony formation, inducing S cell cycle arrest, ROS production, and increasing MMP. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 These authors contributed equally to this article. |
ISSN: | 1420-3049 1420-3049 |
DOI: | 10.3390/molecules25010007 |