Peptide based hydrogels for cancer drug release: modulation of stiffness, drug release and proteolytic stability of hydrogels by incorporating D-amino acid residue(s)

• Published in: Chemical communications (Cambridge, England) Vol. 52; no. 28; pp. 5045 - 5048
• Main Authors: Basu, Kingshuk, Baral, Abhishek, Basak, Shibaji, Dehsorkhi, Ashkan, Nanda, Jayanta, Bhunia, Debmalya, Ghosh, Surajit, Castelletto, Valeria, Hamley, Ian W., Banerjee, Arindam
• Format: Journal Article
• Language: English
• Published: CAMBRIDGE Royal Soc Chemistry 11.04.2016
• Subjects: Amino Acids - chemistry; Antineoplastic Agents - administration & dosage; Cancer; Cell Survival; Chemistry; Chemistry, Multidisciplinary; Drug Carriers - chemistry; Drug Delivery Systems; Drug Liberation - drug effects; Humans; Hydrogels; Hydrogels - chemical synthesis; Hydrogels - chemistry; MCF-7 Cells; Modulation; Molecular Structure; Neoplasms - drug therapy; Peptides - chemistry; Physical Sciences; Proteolysis; Releasing; Residues; Science & Technology; Stability; Stiffness; BETA-SHEET; DOXORUBICIN; ENCAPSULATION; PHYSIOLOGICAL PH; NANOSTRUCTURES; BIOMATERIALS; SUPRAMOLECULAR HYDROGELS; SUSTAINED-RELEASE; GEL; DELIVERY
• ISSN: 1359-7345; 1364-548X
• DOI: 10.1039/c6cc01744d

Synthetic tripeptide based noncytotoxic hydrogelators have been discovered for releasing an anticancer drug at physiological pH and temparature. Interestingly, gel stiffness, drug release capacity and proteolytic stability of these hydrogels have been successfully modulated by incorporating D-amino acid residues, indicating their potential use for drug delivery in the future.