Matrix-producing metaplastic breast carcinoma - a rare malignancy

Metaplastic breast carcinomas are ductal carcinomas that undergo metaplasia into non-glandular growth patterns. They are very rare, accounting for less than 1% of all invasive breast carcinomas. A 33-year-old female patient presented with a lump in her left breast. Axillary lymph nodes were not palp...

Full description

Saved in:
Bibliographic Details
Published inThe American journal of case reports Vol. 14; pp. 213 - 215
Main Authors Bhosale, Suresh J, Kshirsagar, Ashok Y, Sulhyan, Soniya R, Sulhyan, Sanjitsingh R, Jagtap, Sunil V
Format Journal Article
LanguageEnglish
Published United States International Scientific Literature, Inc 01.01.2013
Subjects
Online AccessGet full text

Cover

Loading…
More Information
Summary:Metaplastic breast carcinomas are ductal carcinomas that undergo metaplasia into non-glandular growth patterns. They are very rare, accounting for less than 1% of all invasive breast carcinomas. A 33-year-old female patient presented with a lump in her left breast. Axillary lymph nodes were not palpable. FNAC of the lump was positive for malignant cells. The patient underwent modified radical mastectomy with axillary clearance. The histopathological report was matrix-producing carcinoma with infiltrating duct carcinoma. The tumor was positive for immunohistochemical markers keratin, EMA (Epithelial Membrane Antigen), and S100, thus confirming it to be matrix-producing carcinoma breast. After surgery, the patient recovered uneventfully. Matrix-producing breast carcinoma is a rare type of metaplastic carcinoma characterized by a ductal carcinomatous element with direct extension to areas showing cartilaginous or osseous differentiation, lacking an interspersed spindle cell component. It has better prognosis than metaplastic carcinoma. Immunohistochemically, they are positive for keratin, EMA (Epithelial Membrane Antigen), and S100. The tumor, which is matrix-producing, is S100 reactive and nonreactive for cytokeratin. They are usually ER- and PR-negative. The average age of these patients is approximately 58 years. Surgery remains the mainstay of therapy, using either mastectomy or local excision.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Funds Collection
Authors’ Contribution
Data Interpretation
Literature Search
Data Collection
Study Design
Manuscript Preparation
Statistical Analysis
ISSN:1941-5923
1941-5923
DOI:10.12659/AJCR.883958