Prognostic values of soluble CD30 and CD30 gene polymorphisms in heart transplantation

Pretransplant soluble CD30 (sCD30) is a predictor of kidney graft outcome. Its status as a predictor of heart transplant (HT) outcome has not been established. We have studied this question by assessing sCD30 levels and the number of (CCAT)n repeats of the microsatellite in the CD30 promoter region,...

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Published inTransplantation Vol. 81; no. 8; p. 1153
Main Authors Frisaldi, Elisa, Conca, Raffaele, Magistroni, Paola, Fasano, Maria Edvige, Mazzola, Gina, Patanè, Francesco, Zingarelli, Edoardo, Dall'omo, Anna M, Brusco, Alfredo, Amoroso, Antonio
Format Journal Article
LanguageEnglish
Published United States 27.04.2006
Subjects
Adolescent
Adult
Aged
Female
Heart Transplantation - mortality
Humans
Ki-1 Antigen - blood
Ki-1 Antigen - genetics
Male
Microsatellite Repeats
Middle Aged
Polymorphism, Genetic
Prognosis
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Summary:Pretransplant soluble CD30 (sCD30) is a predictor of kidney graft outcome. Its status as a predictor of heart transplant (HT) outcome has not been established. We have studied this question by assessing sCD30 levels and the number of (CCAT)n repeats of the microsatellite in the CD30 promoter region, which is able alone to repress gene transcription, in the sera of 83 HT patients and 77 of their donors. sCD30 was non-significantly increased in the patients, whereas there were no differences in the CD30 microsatellite allele frequencies. A negative correlation between the number of (CCAT)n and sCD30 levels was evident in the donors. Patients with pretransplant sCD30<or=30 U/ml displayed a significantly better survival. In conclusion, sCD30 levels are predictive of HT outcome.
ISSN:0041-1337
DOI:10.1097/01.tp.0000205181.31604.09