Sensitive and efficient determination of gabapentin in human serum based on capillary electrophoresis with laser-induced fluorescence detection
A sensitive and efficient analytical method for gabapentin ( GBP ) in human serum based on capillary electrophoresis ( CE ) with laser-induced fluorescence ( LIF ) detection has been established. 6-Oxy-( N -succinimidyl acetate)-9-(2′-methoxycarbonyl) fluorescein ( SAMF ), a new synthesized fluoresc...
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Published in | Journal of analytical chemistry (New York, N.Y.) Vol. 68; no. 7; pp. 639 - 645 |
---|---|
Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
Dordrecht
SP MAIK Nauka/Interperiodica
01.07.2013
Springer |
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Abstract | A sensitive and efficient analytical method for gabapentin (
GBP
) in human serum based on capillary electrophoresis (
CE
) with laser-induced fluorescence (
LIF
) detection has been established. 6-Oxy-(
N
-succinimidyl acetate)-9-(2′-methoxycarbonyl) fluorescein (
SAMF
), a new synthesized fluorescent reagent, was used for precolumn derivatization of the non-fluorescent drug in serum. γ-Aminobutyric acid (
GABA
) was used as an internal standard (
I.S.
). The best derivative condition was obtained in phosphate buffer (pH 8) at room temperature for 10 min. Optimal separation and detection were obtained with a background electrolyte (
BGE
) of 3.5 × 10
−2
M phosphate buffer (pH 5.5) and laser-induced fluorescence detection excited at 473 nm. The method developed for GBP was linear over the concentration range of 4.0 × 10
−9
to 4.0 × 10-7 M. The concentration limit of detection was 2.0 × 10
−10
M (signal-to-noise ratio = 3). The sensitive method was used for the determination of GBP in serum samples. |
---|---|
AbstractList | A sensitive and efficient analytical method for gabapentin (GBP) in human serum based on capillary electrophoresis (CE) with laser-induced fluorescence (LIF) detection has been established. 6-Oxy-(7-Vsuccinimidyl acetate)-9-(2'-methoxycarbonyl) fluorescein (SAMF), a new synthesized fluorescent reagent, was used for precolumn derivatization of the non-fluorescent drug in serum. γ-Aminobutyric acid (GABA) was used as an internal standard (I.S.). The best derivative condition was obtained in phosphate buffer (pH 8) at room temperature for 10 min. Optimal separation and detection were obtained with a background electrolyte (BGE) of 3.5 x [10.sup.-2] M phosphate buffer (pH 5.5) and laser-induced fluorescence detection excited at 473 nm. The method developed for GBP was linear over the concentration range of 4.0 x [10.sup.-9] to 4.0 x [10.sup.-7] M. The concentration limit of detection was 2.0 x [10.sup.-10] M (signal-to-noise ratio = 3). The sensitive method was used for the determination of GBP in serum samples. A sensitive and efficient analytical method for gabapentin ( GBP ) in human serum based on capillary electrophoresis ( CE ) with laser-induced fluorescence ( LIF ) detection has been established. 6-Oxy-( N -succinimidyl acetate)-9-(2′-methoxycarbonyl) fluorescein ( SAMF ), a new synthesized fluorescent reagent, was used for precolumn derivatization of the non-fluorescent drug in serum. γ-Aminobutyric acid ( GABA ) was used as an internal standard ( I.S. ). The best derivative condition was obtained in phosphate buffer (pH 8) at room temperature for 10 min. Optimal separation and detection were obtained with a background electrolyte ( BGE ) of 3.5 × 10 −2 M phosphate buffer (pH 5.5) and laser-induced fluorescence detection excited at 473 nm. The method developed for GBP was linear over the concentration range of 4.0 × 10 −9 to 4.0 × 10-7 M. The concentration limit of detection was 2.0 × 10 −10 M (signal-to-noise ratio = 3). The sensitive method was used for the determination of GBP in serum samples. A sensitive and efficient analytical method for gabapentin (GBP) in human serum based on capillary electrophoresis (CE) with laser-induced fluorescence (LIF) detection has been established. 6-Oxy-(7-Vsuccinimidyl acetate)-9-(2'-methoxycarbonyl) fluorescein (SAMF), a new synthesized fluorescent reagent, was used for precolumn derivatization of the non-fluorescent drug in serum. γ-Aminobutyric acid (GABA) was used as an internal standard (I.S.). The best derivative condition was obtained in phosphate buffer (pH 8) at room temperature for 10 min. Optimal separation and detection were obtained with a background electrolyte (BGE) of 3.5 x [10.sup.-2] M phosphate buffer (pH 5.5) and laser-induced fluorescence detection excited at 473 nm. The method developed for GBP was linear over the concentration range of 4.0 x [10.sup.-9] to 4.0 x [10.sup.-7] M. The concentration limit of detection was 2.0 x [10.sup.-10] M (signal-to-noise ratio = 3). The sensitive method was used for the determination of GBP in serum samples. Keywords: gabapentin, 6-oxy-(7V-succinimidyl acetate)-9-(2'-methoxycarbonyl) fluorescein, capillary electrophoresis, laser-induced fluorescence detection, γ-aminobutyric acid DOI: 10.1134/S1061934813070071 |
Audience | Academic |
Author | Li, Cong Cao, Li-Wei Hu, Yang Meng, Jian-Xin Liang, Si-Liu |
Author_xml | – sequence: 1 givenname: Li-Wei surname: Cao fullname: Cao, Li-Wei organization: Department of Chemistry, Jinan University – sequence: 2 givenname: Yang surname: Hu fullname: Hu, Yang organization: Department of Chemistry, Jinan University – sequence: 3 givenname: Si-Liu surname: Liang fullname: Liang, Si-Liu organization: Department of Chemistry, Jinan University – sequence: 4 givenname: Cong surname: Li fullname: Li, Cong organization: Department of Chemistry, Jinan University – sequence: 5 givenname: Jian-Xin surname: Meng fullname: Meng, Jian-Xin organization: Department of Chemistry, Jinan University |
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Keywords | 6-oxy- laser-induced fluorescence detection gabapentin succinimidyl acetate)-9-(2′-methoxycarbonyl) fluorescein γ-aminobutyric acid capillary electrophoresis |
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Snippet | A sensitive and efficient analytical method for gabapentin (
GBP
) in human serum based on capillary electrophoresis (
CE
) with laser-induced fluorescence (... A sensitive and efficient analytical method for gabapentin (GBP) in human serum based on capillary electrophoresis (CE) with laser-induced fluorescence (LIF)... |
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SubjectTerms | Analytical Chemistry Chemical properties Chemistry Chemistry and Materials Science Composition Electrophoresis Fluorescence Gabapentin Identification and classification Methods Pharmaceutical chemistry Serum |
Title | Sensitive and efficient determination of gabapentin in human serum based on capillary electrophoresis with laser-induced fluorescence detection |
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