A new sesquiterpenoid from the aconitum-derived fungus Aspergillus fumigatus M1

A new bergamotane sesquiterpenoid, fumigatanol (1), along with nine known compounds (2-10) were isolated from the Aconitum-derived fungus Aspergillus fumigatus M1. Their structures were established on the basis of extensive spectroscopic analyses, ECD experiment and NMR computational method. Antibac...

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Published inNatural product research Vol. 37; no. 20; pp. 3443 - 3451
Main Authors Ding, Hao, Wang, Jia-Peng, Deng, Si-Ping, Gan, Jun-Li, Li, Bing-Xian, Yao, Ling-Ling, Zhang, Sheng-Qi, Cai, Le, Ding, Zhong-Tao
Format Journal Article
LanguageEnglish
Published England Taylor & Francis 18.10.2023
Taylor & Francis Ltd
Subjects
Aspergillus fumigatus
Aspergillus fumigatus M1
bergamotane sesquiterpenoid
Cytotoxicity
Fumigatanol
Fungi
NMR
Nuclear magnetic resonance
sesquiterpenoids
spectroscopy
bergamotane sesquiterpenoid
Fumigatanol
Aspergillus fumigatus M1
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Summary:A new bergamotane sesquiterpenoid, fumigatanol (1), along with nine known compounds (2-10) were isolated from the Aconitum-derived fungus Aspergillus fumigatus M1. Their structures were established on the basis of extensive spectroscopic analyses, ECD experiment and NMR computational method. Antibacterial and cytotoxic activities of compound 1 were evaluated and no obvious antibacterial and cytotoxic activities were observed at concentrations of 256 μg/mL and 40.00 μM, respectively.
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ISSN:1478-6419
1478-6427
1478-6427
DOI:10.1080/14786419.2022.2080207