Multifunctional nanoparticle platforms for in vivo MRI enhancement and photodynamic therapy of a rat brain cancer

• Published in: Journal of magnetism and magnetic materials Vol. 293; no. 1; pp. 404 - 410
• Main Authors: Kopelman, Raoul, Lee Koo, Yong-Eun, Philbert, Martin, Moffat, Bradford A., Ramachandra Reddy, G., McConville, Patrick, Hall, Daniel E., Chenevert, Thomas L., Bhojani, Mahaveer Swaroop, Buck, Sarah M., Rehemtulla, Alnawaz, Ross, Brian D.
• Format: Journal Article Conference Proceeding
• Language: English
• Published: Amsterdam Elsevier B.V 01.05.2005; Elsevier Science
• Subjects: Cancer; Condensed matter: electronic structure, electrical, magnetic, and optical properties; Exact sciences and technology; Magnetic properties and materials; Molecular imaging; MRI contrast agent; Nanoparticles; Photodynamic therapy (PDT); Physics; Polyacrylamide (PAA); Polyethylene glycol (PEG); Molecular imaging; Nanoparticles; Polyacrylamide (PAA); Photodynamic therapy (PDT); Polyethylene glycol (PEG); MRI contrast agent; Cancer; Polyethylenes; Imaging; NMR imaging; Real time
• ISSN: 0304-8853
• DOI: 10.1016/j.jmmm.2005.02.061

A paradigm for brain cancer detection, treatment, and monitoring is established. Multifunctional biomedical nanoparticles (30–60 nm) containing photosensitizer externally deliver reactive oxygen species (ROS) to cancer cells while simultaneously enhancing magnetic resonance imaging (MRI) contrast providing real-time tumor kill measurement. Plasma residence time control and specific cell targeting are achieved. A 5 min treatment in rats halted and even reversed in vivo tumor growth after 3–4 days post-treatment.