Age-related changes of human aortic flow wave velocity measured noninvasively by magnetic resonance imaging

We have used magnetic resonance imaging with cine velocity mapping to measure flow wave velocity in the thoracic aorta of 20 healthy volunteers of different ages. We have also studied the relationship between propagation of flow wave velocity and regional aortic compliance. Aortic flow velocity incr...

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Bibliographic Details
Published inJournal of applied physiology (1985) Vol. 74; no. 1; p. 492
Main Authors Mohiaddin, R H, Firmin, D N, Longmore, D B
Format Journal Article
LanguageEnglish
Published United States 01.01.1993
Subjects
Adolescent
Adult
Aging - physiology
Aorta - anatomy & histology
Aorta - diagnostic imaging
Aorta - physiology
Aorta, Thoracic - anatomy & histology
Aorta, Thoracic - physiology
Compliance
Echocardiography
Female
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Pulmonary Artery - physiology
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Summary:We have used magnetic resonance imaging with cine velocity mapping to measure flow wave velocity in the thoracic aorta of 20 healthy volunteers of different ages. We have also studied the relationship between propagation of flow wave velocity and regional aortic compliance. Aortic flow velocity increased linearly with age (r = 0.87), and there was a significant difference between the youngest decade [age 10-19, mean velocity 4.3 +/- 0.7 (SD) m/s] and the oldest decade studied (age 50-59, mean velocity 7.2 +/- 0.2 m/s). Flow wave velocity (m/s) was negatively correlated with ascending aortic compliance (microliter/mmHg) (r = -0.75). Magnetic resonance imaging is a noninvasive method for measurement of aortic flow wave velocity that is an important parameter in assessing arterial wall mechanics and blood flow dynamic.
ISSN:8750-7587
DOI:10.1152/jappl.1993.74.1.492