Rho family GTPases: more than simple switches

Rho family GTPases control a large variety of biological processes. Cycling of Rho proteins between the GDP-bound and the GTP-bound state is controlled by several classes of regulatory proteins. In this review, we discuss the signal-transduction mechanisms that control these regulators. We will emph...

Full description

Saved in:
Bibliographic Details
Published inTrends in Cell Biology Vol. 10; no. 10; pp. 415 - 419
Main Authors Symons, Marc, Settleman, Jeff
Format Book Review Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.10.2000
Subjects
Cell signalling
Cytoskeleton
GAP
GDI
GEF
GTPase
Guanosine Diphosphate - metabolism
Guanosine Triphosphate - metabolism
Plasma membrane
Rho
rho GTP-Binding Proteins - metabolism
Signal Transduction - physiology
Cell signalling
GAP
Plasma membrane
Cell biology
Rho
Cytoskeleton
GEF
Biochemistry
GTPase
GDI
Online AccessGet full text

Cover

More Information
Summary:Rho family GTPases control a large variety of biological processes. Cycling of Rho proteins between the GDP-bound and the GTP-bound state is controlled by several classes of regulatory proteins. In this review, we discuss the signal-transduction mechanisms that control these regulators. We will emphasize the subcellular localization of Rho GTPases and their regulatory proteins and the role of GTP hydrolysis in signal transmission.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:0962-8924
1879-3088
DOI:10.1016/S0962-8924(00)01832-8