Partial laryngectomy as salvage surgery for radiation failures in T1-T2 laryngeal cancer

• Published in: Head & neck Vol. 20; no. 7; pp. 630 - 633
• Main Authors: Rodríguez-Cuevas, Sergio, Labastida, Sonia, Gonzalez, Domingo, Briseño, Nicolas, Cortes, Hector
• Format: Journal Article
• Language: English
• Published: New York Wiley Subscription Services, Inc., A Wiley Company 01.10.1998; John Wiley & Sons
• Subjects: Adult; Aged; Aged, 80 and over; Biological and medical sciences; Carcinoma, Squamous Cell - mortality; Carcinoma, Squamous Cell - radiotherapy; Carcinoma, Squamous Cell - surgery; Female; Glottis; Head and neck surgery. Maxillofacial surgery. Dental surgery. Orthodontics; Humans; Laryngeal Neoplasms - mortality; Laryngeal Neoplasms - radiotherapy; Laryngeal Neoplasms - surgery; laryngectomy; Laryngectomy - methods; Lymph Node Excision; Male; Medical sciences; Middle Aged; Neoplasm Recurrence, Local - mortality; Neoplasm Recurrence, Local - surgery; partial laryngectomy; radiotherapy failure; Retrospective Studies; Salvage Therapy; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Surgery of the upper aerodigestive tract; Survival Rate; Treatment Failure; Human; Recurrence; Squamous cell carcinoma; Prognosis; Malignant tumor; Radiotherapy; Laryngectomy; Retrospective; Time lag; Treatment; Partial; Surgery; ENT disease; Larynx; Larynx disease; Salvage treatment; Failure
• ISSN: 1043-3074; 1097-0347
• DOI: 10.1002/(SICI)1097-0347(199810)20:7<630::AID-HED9>3.0.CO;2-K

Background Radiotherapy is the treatment of choice for early glottic carcinoma. Thirteen percent to 24% of patients require salvage surgery. To evaluate time of recurrence, site, and locoregional control, we retrospectively reviewed 29 patients treated from 1981 to 1996. Methods There were 28 men and 1 woman. Mean age was 63 years. Twenty were T1 (69%) and 9 were T2 (31%). Median time of recurrence was 14.5 months. In 14 patients (52%), a partial laryngectomy was done, and 13 patients had a total laryngectomy. Two refused surgery. Results One patient relapsed after salvage surgery. Five‐year survival after salvage surgery was 92%, with no difference between partial and total laryngectomy (p = 0.2). Conclusions Recurrences after failure to radiotherapy in T1–T2 glottic carcinoma could be salvaged with partial laryngectomy in 52% of patients, preserving laryngeal function, with adequate tumor control and acceptable morbidity. The selection of the surgical procedure is based on the tumor extension. © 1998 John Wiley & Sons, Inc. Head Neck 20: 630–633, 1998.