Cancer metastasis facilitated by developmental pathways: Sonic hedgehog, Notch, and bone morphogenic proteins
This review will highlight the significance of three critical pathways in developmental biology and our emerging understanding of their roles in regulating tumor metastasis: Bone morphogenic protein (BMP), Notch and Sonic hedgehog (SHH). We will discuss parallels between their known roles in develop...
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Published in | Journal of cellular biochemistry Vol. 102; no. 4; pp. 829 - 839 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
Hoboken
Wiley Subscription Services, Inc., A Wiley Company
01.11.2007
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Subjects | |
Online Access | Get full text |
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Summary: | This review will highlight the significance of three critical pathways in developmental biology and our emerging understanding of their roles in regulating tumor metastasis: Bone morphogenic protein (BMP), Notch and Sonic hedgehog (SHH). We will discuss parallels between their known roles in development and how these processes can be used by tumor cells to create microenvironments that enhance tumor metastasis. That tumor cells usurp pathways critical to the developing embryo is not surprising, as many of the normal developmental programs include processes that are also seen during tumor progression to a metastatic phenotype, including epithelial to mesenchymal transition (EMT), tissue specific morphogenesis, cellular motility and invasion. BMPs are involved in EMT, contribute to tissue specific morphogenesis, and are expressed in highly‐metastatic tumor cells. BMPs have also been hypothesized to have a role in the establishment of a pre‐neoplastic niche. Notch and SHH facilitate neovascularization, angiogenesis, EMT and can contribute to the maintenance of highly‐metastatic tumor stem cells. J. Cell. Biochem. 102: 829–839, 2007. © 2007 Wiley‐Liss, Inc. |
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Bibliography: | ark:/67375/WNG-6R3SN38F-P NIH - No. 5R01 CA57362 istex:A843FC3AA798C577DDA04D8457CF0BF84E34919A ArticleID:JCB21509 ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 |
ISSN: | 0730-2312 1097-4644 |
DOI: | 10.1002/jcb.21509 |