Severe arteriolar lesion mimicking drug-induced arteriolopathy in a long-term surviving renal allograft

• Published in: Clinical transplantation Vol. 16; no. s8; pp. 72 - 76
• Main Authors: Nazneen, Arifa, Nishikido, Masaharu, Koga, Shigehiko, Kanetake, Hiroshi, Liu, Diange, Harada, Takashi, Taguchi, Takashi
• Format: Journal Article Conference Proceeding
• Language: English
• Published: Oxford, UK Blackwell Publishers 01.01.2002; Blackwell
• Subjects: Adult; arteriolar hyalinosis; Arterioles - ultrastructure; arteriolosclerosis; Biological and medical sciences; Biopsy; Combined surgery. Multiple transplantations; Diagnosis, Differential; drug-induced arteriolopathy; Graft Rejection - pathology; Humans; Immunosuppression - adverse effects; Kidney Diseases - chemically induced; Kidney Diseases - pathology; Kidney Transplantation; long-term survivor; Male; Medical sciences; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Glomerulonephritis; long-term survivor; kidney transplantation; Cardiovascular disease; Male; arteriolosclerosis; Transplantation; Homotransplantation; Kidney; Vascular disease; Surgery; arteriolar hyalinosis; Adult; Complication; Diagnosis; Human; Kidney disease; Urinary system disease; Long term; Survival; Case study; Pathology; Chemotherapy; Treatment; Microangiopathy; Biopsy; drug-induced arteriolopathy; Severity score; Immunosuppressive agent
• ISSN: 0902-0063; 1399-0012
• DOI: 10.1034/j.1399-0012.16.s8.13.x

: We report severe arteriolar lesion mimicking drug‐induced arteriolopathy in a renal allograft of a 37‐year‐old Japanese male, who has been treated by conventional immunosuppressive therapy but not administered cyclosporin or tacrolimus for 16 years after renal transplantation. Renal biopsy also showed glomerular changes including transplant glomerulopathy and features of chronic vascular rejection. The cause of the arteriolar lesion remains uncertain. Although its pathogenesis may be multi‐factorial, long‐term usage of conventional immunosuppressive agents and/or vascular rejection may contribute to the occurrence of the arteriolar lesion. We propose that biopsy study is needed for further understanding of histopathological behaviours of renal grafts in long‐term survivors.