Validation of high-performance liquid chromatographic methods for analysis of sustained-release preparations containing nitroglycerin, isosorbide dinitrate, or pentaerythritol tetranitrate

The assay of sustained-release tablets or capsules containing nitroglycerin, isosorbide dinitrate, or pentaerythritol tetranitrate by high-performance liquid chromatography is described. Acetonitrile was found to be the sample preparation solvent with the most general applicability to these products...

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Bibliographic Details
Published inJournal of pharmaceutical sciences Vol. 72; no. 2; p. 124
Main Authors Gelber, L, Papas, A N
Format Journal Article
LanguageEnglish
Published United States 01.02.1983
Subjects
Acetonitriles
Chromatography, High Pressure Liquid - methods
Delayed-Action Preparations
Dimethyl Sulfoxide
Isosorbide Dinitrate - analysis
Nitroglycerin - analysis
Pentaerythritol Tetranitrate - analysis
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Summary:The assay of sustained-release tablets or capsules containing nitroglycerin, isosorbide dinitrate, or pentaerythritol tetranitrate by high-performance liquid chromatography is described. Acetonitrile was found to be the sample preparation solvent with the most general applicability to these products. Anisole was used as an internal standard for nitroglycerin and pentaerythritol tetranitrate, while 4-chloroacetanilide was used for isosorbide dinitrate. The method, which uses a C18 bonded-phase column, a methanol-water mobile phase, and 214-nm detection, was shown to be accurate, linear, and reproducible.
ISSN:0022-3549
1520-6017
DOI:10.1002/jps.2600720207