Plastic Scintillator‐Based Microfluidic Devices for Miniaturized Detection of Positron Emission Tomography Radiopharmaceuticals

A miniaturized radio‐HPLC detector has been developed comprising a microfluidic device fabricated from plastic scintillator in combination with a silicon photomultiplier light sensor, and tested with samples containing a positron‐emitting radionuclide, [18F]fluoride. This cost‐effective, small footp...

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Published inChemistry : a European journal Vol. 24; no. 52; pp. 13749 - 13753
Main Authors Tarn, Mark D., Kızılyer, Nuray Yavuzkanat, Esfahani, Mohammad M. N., Joshi, Pankaj, Brown, Nathaniel J., Pamme, Nicole, Jenkins, David G., Archibald, Stephen J.
Format Journal Article
LanguageEnglish
Published Weinheim Wiley Subscription Services, Inc 18.09.2018
Subjects
Chemistry
Control systems
Cost analysis
Emission analysis
Emission standards
Good Manufacturing Practice
High-performance liquid chromatography
Liquid chromatography
microfluidics
Photomultiplier tubes
plastic scintillator
Positron emission
Positron emission tomography
Positrons
Quality control
Radioisotopes
radiopharmaceuticals
Scintillation counters
silicon photomultiplier
Tomography
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Summary:A miniaturized radio‐HPLC detector has been developed comprising a microfluidic device fabricated from plastic scintillator in combination with a silicon photomultiplier light sensor, and tested with samples containing a positron‐emitting radionuclide, [18F]fluoride. This cost‐effective, small footprint analytical tool is ideal for incorporation into integrated quality control systems for the testing of positron emission tomography (PET) radiopharmaceuticals to good manufacturing practice (GMP) standards. A miniaturised radio‐HPLC detector for the QC analysis of positron emission tomography (PET) radiotracers is reported, based on a microfluidic device fabricated out of plastic scintillator and a small footprint, low‐cost silicon photomultiplier (SiPM) light sensor. The platform enabled real‐time detection of [18F]fluoride radioisotope with low injection volumes and clinically relevant levels of activity.
Bibliography:These authors contributed equally to this work.
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ISSN:0947-6539
1521-3765
DOI:10.1002/chem.201802395