Teratogenic potential of cocaine hydrochloride in CF-1 mice

This investigation revealed that cocaine hydrochloride was teratogenic when administered in nontoxic doses to gravid CF-1 mice on Days 7-12 of gestation. The teratogenic susceptibility of the CF-1 mouse fetus to cocaine hydrochloride was evident throughout this portion of the gestation period. The e...

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Bibliographic Details
Published inJournal of pharmaceutical sciences Vol. 69; no. 6; p. 703
Main Authors Mahalik, M P, Gautieri, R F, Mann, Jr, D E
Format Journal Article
LanguageEnglish
Published United States 01.06.1980
Subjects
Abnormalities, Drug-Induced
Animals
Bone and Bones - abnormalities
Cocaine - toxicity
Eye Abnormalities
Female
Fetal Resorption - chemically induced
Gestational Age
Male
Maternal-Fetal Exchange
Mice
Pregnancy
Sex Factors
Teratogens
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Summary:This investigation revealed that cocaine hydrochloride was teratogenic when administered in nontoxic doses to gravid CF-1 mice on Days 7-12 of gestation. The teratogenic susceptibility of the CF-1 mouse fetus to cocaine hydrochloride was evident throughout this portion of the gestation period. The early appearance of eye defects and the occurrence of skeletal defects later in gestation after cocaine hydrochloride challenge paralleled the sequence of ontogenesis.
ISSN:0022-3549
DOI:10.1002/jps.2600690625