Adenocarcinoma of duodenum and ampulla of Vater: Clinicopathology study and expression of p53, c-neu, TGF-α, CEA, and EMA

• Published in: Journal of surgical oncology Vol. 61; no. 2; pp. 100 - 105
• Main Authors: Zhu, Liyin, Kim, Kitai, Domenico, Don R., Appert, Hubert E., Howard, John M.
• Format: Journal Article
• Language: English
• Published: New York Wiley Subscription Services, Inc., A Wiley Company 01.02.1996; Wiley-Liss
• Subjects: Adenocarcinoma - metabolism; Adenocarcinoma - pathology; Adult; Aged; Aged, 80 and over; Ampulla of Vater; ampullary adenocarcinoma; Antigens, Neoplasm - analysis; Biological and medical sciences; c-neu; Carcinoembryonic Antigen - analysis; CEA; Common Bile Duct Neoplasms - metabolism; Common Bile Duct Neoplasms - pathology; duodenal adenocarcinoma; Duodenal Neoplasms - metabolism; Duodenal Neoplasms - pathology; EMA; Female; Gastroenterology. Liver. Pancreas. Abdomen; Humans; Immunohistochemistry; Male; Medical sciences; Middle Aged; Mucin-1 - analysis; Neoplasm Proteins - analysis; p53; Receptor, ErbB-2 - analysis; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus; survival; TGF-α; Transforming Growth Factor alpha - analysis; Tumor Suppressor Protein p53 - analysis; Tumors; Adenocarcinoma; Histological grading; Human; Prognosis; Duodenum; Cytokine; Exploration; Tumoral marker; Malignant tumor; Gene expression; Vater ampulla; p53 gene; Carcinoembryonic antigen; Clinical stage; Polypeptide; Digestive diseases; Intestinal disease; Transforming growth factor α; Protooncogene; Growth factor; Tumor suppressor gene
• ISSN: 0022-4790; 1096-9098
• DOI: 10.1002/(SICI)1096-9098(199602)61:2<100::AID-JSO3>3.0.CO;2-G

Oncogenes, tumor suppressor genes, and growth factors are being explored as to their role in the initiation and progression of most neoplasms, but little information exists on the expression of oncoproteins or growth factors in adenocarcinoma of the duodenum or ampulla of Vater. This report covers expressions of p53, c‐neu, TGF‐α, CEA, and EMA in duodenal adenocarcinoma and ampullary adenocarcinoma, as well as correlations between expressions and tumor stage, histological grade and patient survival. The expression of p53, c‐neu, TGF‐α, CEA, and EMA has been studied in 15 duodenal adenocarcinomas and in eight ampullary adenocarcinomas by avidin‐biotin‐peroxidase complex indirect immunoperoxidase technique. The positive reaction for p53, c‐neu, TGF‐α, CEA, and EMA in duodenal adenocarcinoma was 20%, 60%, 60%, 73%, and 100%, respectively, and in ampullary adenocarcinoma, 13%, 100%, 50%, 63%, and 100%. Among the duodenal tumors, C‐neu and p53 expression was noted more frequently in groups with high histological grades. Patients with c‐neu positive duodenal adenocarcinoma had a shorter survival than the patients with c‐neu negative duodenal adenocarcinoma (P < 0.01). C‐neu product may serve as an unfavorable prognostic indicator in duodenal adenocarcinoma. No statistically significant correlation was found between the expressions of CEA, EMA, p53, and TGF‐α and patient survival, tumor stage, or histological grade in either duodenal or ampullary adenocarcinomas. © 1996 Wiley‐Liss, Inc.