Recurrence in patients following curative resection of early gastric carcinoma

• Published in: Journal of surgical oncology Vol. 98; no. 6; pp. 411 - 414
• Main Authors: Wu, Benyan, Wu, Daohong, Wang, Mengwei, Wang, Gangshi
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.11.2008
• Subjects: Adult; Age Factors; Aged; Aged, 80 and over; Carcinoma - genetics; Carcinoma - pathology; Carcinoma - surgery; early gastric cancer; family history of cancer; Female; Follow-Up Studies; Gastrectomy; Humans; lymphatic involvement; Male; Middle Aged; Multivariate Analysis; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Recurrence, Local - genetics; Neoplasm Recurrence, Local - pathology; recurrence; Retrospective Studies; Risk Factors; Stomach Neoplasms - genetics; Stomach Neoplasms - pathology; Stomach Neoplasms - surgery; the elderly
• ISSN: 0022-4790; 1096-9098
• DOI: 10.1002/jso.21133

Objective Post‐gastrectomy recurrences of early gastric cancer occur in a few cases. We investigated the outcome of early gastric cancer patients treated surgically, with special respect to the risk factor(s) for tumor recurrence. Patients and Methods A total of 308 patients with mono‐foci early gastric cancer underwent curative surgical resection. Clinicopathological variables and tumor recurrence patterns were analyzed retrospectively. Results Recurrence was observed in 30 out of 245 patients (12.24%) who had completed follow‐up. The median interval from surgery to diagnosis of recurrence was 28 (range 3–188) months. Hematogenous recurrence (3.27%) was twice as frequent as peritoneal recurrence (1.63%). Gastric stump cancer occurred in 9 patients (3.67%), anastomotic recurrence in 7 patients (2.86%) and lymphatic recurrence in 4 patients (1.63%). Older patients (≥60 years old) had a more frequent recurrence rate than younger patients (P < 0.05). Multivariate analyses identified lymph node metastasis and depth of invasion as risk factors of recurrence. All the patients with a positive family history of cancer got recurrence within 3 years after surgery. Conclusions Early gastric cancer patients, who were elderly, had lymphatic and submucosal involvement, and patients with a positive family history of cancer, tended to have a greater risk of recurrence. J. Surg. Oncol. © 2008 Wiley‐Liss, Inc.