Release of bovine serum albumin from a hydrogel-cored biodegradable polymer fiber
We have developed a novel biodegradable, polymeric fiber construct that is coextruded using a wet‐spinning process into a core‐sheath format with a polysaccharide pre‐hydrogel solution as the core fluid and poly(L‐lactic acid) (PLLA) as the sheath. The biodegradable, biocompatible fibers were extrud...
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Published in | Biopolymers Vol. 81; no. 6; pp. 419 - 427 |
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Main Authors | , |
Format | Journal Article |
Language | English |
Published |
Hoboken
Wiley Subscription Services, Inc., A Wiley Company
15.04.2006
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Subjects | |
Online Access | Get full text |
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Summary: | We have developed a novel biodegradable, polymeric fiber construct that is coextruded using a wet‐spinning process into a core‐sheath format with a polysaccharide pre‐hydrogel solution as the core fluid and poly(L‐lactic acid) (PLLA) as the sheath. The biodegradable, biocompatible fibers were extruded from polymeric emulsions comprised of solutions of various molecular weights of PLLA dissolved in chloroform and containing dispersed, protein‐free aqueous phases comprising up to 10% of the emulsion volume. Biologically sensitive agents can be loaded via a dispersed aqueous phase in the polymer, and/or directly into the polysaccharide. We show that this core‐sheath fiber format will load a model protein that can be delivered for extended periods in vitro. Bovine serum albumin (BSA) was loaded into the fiber core as a model protein. We have shown that the greater the volume of the protein‐free aqueous phase dispersed into the polymeric continuous‐phase emulsion, the greater the total release of BSA encapsulated by a core gel comprised of 1% sodium alginate solution. We conclude this fiber format provides a promising vehicle for in vivo delivery of biological molecules. Its biocompatibility and biodegradability also allow for its use as a possible substrate for tissue engineering applications. © 2006 Wiley Periodicals, Inc. Biopolymers 81: 419–427, 2006
This article was originally published online as an accepted preprint. The “Published Online” date corresponds to the preprint version. You can request a copy of the preprint by emailing the Biopolymers editorial office at biopolymers@wiley.com |
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Bibliography: | ark:/67375/WNG-D01LFD96-M University of Texas at Arlington (UTA) istex:645EC7D654547FF6BFAA01D0B89E1EDB37201649 NIH - No. REP grant 1430004 (UTA); No. ATP grant 010019-0036-1997 (THECB); No. R01 NS 40592-01 (NIH) Texas Higher Education Coordinating Board (THECB) ArticleID:BIP20442 |
ISSN: | 0006-3525 1097-0282 |
DOI: | 10.1002/bip.20442 |