Intensity of immunosuppressive therapy and the incidence of pneumocystis carinii pneumonitis

One hundred and forty‐nine children with acute lymphocytic leukemia treated according to a prospective protocol were randomized after induction of remission and central nervous system (CNS) irradiation to receive maintenance chemotherapy with 1, 2, 3, or 4 chemotherapy agents. The incidence of P. ca...

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Bibliographic Details
Published inCancer Vol. 36; no. 6; pp. 2004 - 2009
Main Authors Hughes, Walter T., Feldman, Sandor, Aur, Rhomes J. A., Verzosa, Manuel S., Hustu, H. Omar, Simone, Joseph V.
Format Journal Article
LanguageEnglish
Published New York Wiley Subscription Services, Inc., A Wiley Company 01.12.1975
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Summary:One hundred and forty‐nine children with acute lymphocytic leukemia treated according to a prospective protocol were randomized after induction of remission and central nervous system (CNS) irradiation to receive maintenance chemotherapy with 1, 2, 3, or 4 chemotherapy agents. The incidence of P. carinii pneumonitis (PCP) was 5.0, 2.3, 2.2, and 22.4%, respectively, during the period of maintenance therapy. An additional 31 patients enrolled in the same study were placed in special categories to receive three drugs for maintenance plus supplemental chemotherapy or irradiation because of CNS leukemia on admission, remission failure, mediastinal mass, or generalized lymphosarcoma without bone marrow involvement. The incidences of PCP in these groups were 16.7, 30.0, 35.7, and 0%, respectively, during the period of maintenance therapy.
ISSN:0008-543X
1097-0142
DOI:10.1002/cncr.2820360912