Compression properties of granulations made with binders containing different moisture contents

The role of the granulation moisture content on compression properties of granules made with selected binders was studied. The results suggested that, at lower pressures, higher moisture-containing granules were slightly more compressible than lower moisture-containing granules. However, at higher p...

Full description

Saved in:
Bibliographic Details
Published inJournal of pharmaceutical sciences Vol. 70; no. 10; p. 1134
Main Authors Chowhan, Z T, Chow, Y P
Format Journal Article
LanguageEnglish
Published United States 01.10.1981
Subjects
Drug Compounding
Excipients
Hardness
Humidity
Powders
Pressure
Pyridines
Tablets
Thiophenes
Ticlopidine
Online AccessGet more information

Cover

More Information
Summary:The role of the granulation moisture content on compression properties of granules made with selected binders was studied. The results suggested that, at lower pressures, higher moisture-containing granules were slightly more compressible than lower moisture-containing granules. However, at higher pressures, the reverse was true because of the water lubrication effect. At lower moisture levels, the crushing strength of the tablets was dependent on the binder; at higher moisture levels, binder differences became less significant.
ISSN:0022-3549
1520-6017
DOI:10.1002/jps.2600701011