Parameters of bladder function in pre-, peri-, and postmenopausal continent women without detrusor overactivity

• Published in: Neurourology and urodynamics Vol. 26; no. 3; pp. 356 - 361
• Main Authors: Pfisterer, Mathias H.-D., Griffiths, Derek J., Rosenberg, Lisa, Schaefer, Werner, Resnick, Neil M.
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.01.2007
• Subjects: Adult; age; Aged; Aged, 80 and over; Aging - physiology; bladder function; Female; Humans; Medical Records; Menopause; Middle Aged; Perimenopause; Postmenopause; Premenopause; Urethra - physiology; Urinary Bladder - physiology; urinary tract; Urine; urodynamics; Urodynamics - physiology
• ISSN: 0733-2467; 1520-6777
• DOI: 10.1002/nau.20381

Aims To determine normative data for lower urinary tract function in asymptomatic continent women without detrusor overactivity (DO) across the age span. Methods Healthy female volunteers aged ≥20 years were recruited from the community. Comprehensive assessment included bladder diary, physical examination, uroflowmetry, and videourodynamics. Continent women without history of frequent urgency and without DO were selected. Data on bladder storage, voiding and urethral sphincter function, urine output and frequency are presented for pre‐, peri‐, and postmenopausal women. Results Twenty‐four asymptomatic women (mean age 50.2 years, range 22–80 years) met the inclusion criteria, including 7 pre‐ (29.2 years), 7 peri‐ (48.8 years), and 10 postmenopausal (66.0 years) women. For all subjects, maximum single voided volume in bladder diary was 500 ml and maximum cystometric capacity was 580 ml (median values). Strong desire to void (SDV) was reported at 287, 366, and 425 ml for pre‐, peri‐, and postmenopausal groups, respectively. The maximum flow rate was 25, 32, and 23 ml/sec in uroflowmetry and 23, 24, and 18 ml/sec in pressure‐flow study, respectively. Median post‐void residual volume (PVR) was below 20 ml in all groups. At maximum flow rate subjects voided with detrusor pressures of 29, 26, and 24 cm H2O, respectively. Maximum urethral closure pressure was 94, 74, and 42 cm H2O, respectively. Conclusions We provide normative data on bladder function in asymptomatic, continent, pre‐, peri‐, and postmenopausal women without DO. Neurourol. Urodynam. 26:356–361, 2007. © 2007 Wiley‐Liss, Inc.