Model of interaction of ajmaline with polyvinylpyrrolidone

The chemical shifts in the Fourier transform 13C-NMR spectrum of ajmaline were assigned from consideration of the acetylation shifts and multiplet splitting in the off-resonance decoupled spectrum. On the basis of the assigned signals, the changes of chemical shifts in ajmaline induced by polyvinylp...

Full description

Saved in:
Bibliographic Details
Published inJournal of pharmaceutical sciences Vol. 69; no. 7; p. 824
Main Authors Hosono, T, Tsuchiya, S, Matsumaru, H
Format Journal Article
LanguageEnglish
Published United States 01.07.1980
Subjects
Ajmaline
Chemical Phenomena
Chemistry
Chloroform
Magnetic Resonance Spectroscopy
Molecular Conformation
Povidone
Online AccessGet more information

Cover

More Information
Summary:The chemical shifts in the Fourier transform 13C-NMR spectrum of ajmaline were assigned from consideration of the acetylation shifts and multiplet splitting in the off-resonance decoupled spectrum. On the basis of the assigned signals, the changes of chemical shifts in ajmaline induced by polyvinylpyrrolidone were investigated, and an interaction model of ajmaline with polyvinylpyrrolidone in chloroform was proposed.
ISSN:0022-3549
DOI:10.1002/jps.2600690720