Preventing saphenous vein graft failure: does gene therapy have a role?

Gene therapy potentially allows local delivery and expression of cytokines, growth factors, and other mediators. In spite of increasing knowledge of the human genome, applications in clinical practice are only just beginning. The main limitations of effective clinical gene therapy are safety and low...

Full description

Saved in:
Bibliographic Details
Published inThe Annals of Thoracic Surgery Vol. 76; no. 3; pp. 959 - 966
Main Authors Akowuah, Enoch F, Sheridan, Paul J, Cooper, Graham J, Newman, Christopher
Format Book Review Journal Article
LanguageEnglish
Published New York, NY Elsevier Inc 01.09.2003
Elsevier Science
Subjects
Biological and medical sciences
Genetic Therapy - methods
Graft Rejection - prevention & control
Humans
Medical sciences
Saphenous Vein - transplantation
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Surgery of the heart
29
Human
Pathophysiology
Treatment efficiency
Homograft
Cardiovascular disease
Review
Graft failure
Vascular disease
Prevention
Treatment
Aortocoronary
Bypass
Saphenous vein
Heart disease
Surgery
Graft
Complication
Technique
Gene therapy
Online AccessGet full text

Cover

More Information
Summary:Gene therapy potentially allows local delivery and expression of cytokines, growth factors, and other mediators. In spite of increasing knowledge of the human genome, applications in clinical practice are only just beginning. The main limitations of effective clinical gene therapy are safety and low transfection efficiency. Saphenous vein grafts permit the transfection of the conduit ex vivo. This allows a variety of transfection techniques to be used, enhancing the transfection efficiency while limiting the risk of systemic complications. This review examines the potential mechanisms of gene delivery and genetic targets that may be applied to saphenous vein graft failure.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:0003-4975
1552-6259
DOI:10.1016/S0003-4975(03)00505-8