Unraveling the Neural Circuits: Techniques, Opportunities and Challenges in Epilepsy Research

Epilepsy, a prevalent neurological disorder characterized by high morbidity, frequent recurrence, and potential drug resistance, profoundly affects millions of people globally. Understanding the microscopic mechanisms underlying seizures is crucial for effective epilepsy treatment, and a thorough un...

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Published inCellular and molecular neurobiology Vol. 44; no. 1; p. 27
Main Authors Xiao, Wenjie, Li, Peile, Kong, Fujiao, Kong, Jingyi, Pan, Aihua, Long, Lili, Yan, Xiaoxin, Xiao, Bo, Gong, Jiaoe, Wan, Lily
Format Journal Article
LanguageEnglish
Published New York Springer US 01.12.2024
Springer Nature B.V
Subjects
Biomedical and Life Sciences
Biomedicine
Cell Biology
Drug resistance
Epilepsy
Epilepsy - therapy
Humans
Morbidity
Neural networks
Neurobiology
Neurosciences
Review Paper
Reviews
Seizures
Techniques
Development history
Drug therapy
Neural circuits
Epilepsy
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Summary:Epilepsy, a prevalent neurological disorder characterized by high morbidity, frequent recurrence, and potential drug resistance, profoundly affects millions of people globally. Understanding the microscopic mechanisms underlying seizures is crucial for effective epilepsy treatment, and a thorough understanding of the intricate neural circuits underlying epilepsy is vital for the development of targeted therapies and the enhancement of clinical outcomes. This review begins with an exploration of the historical evolution of techniques used in studying neural circuits related to epilepsy. It then provides an extensive overview of diverse techniques employed in this domain, discussing their fundamental principles, strengths, limitations, as well as their application. Additionally, the synthesis of multiple techniques to unveil the complexity of neural circuits is summarized. Finally, this review also presents targeted drug therapies associated with epileptic neural circuits. By providing a critical assessment of methodologies used in the study of epileptic neural circuits, this review seeks to enhance the understanding of these techniques, stimulate innovative approaches for unraveling epilepsy's complexities, and ultimately facilitate improved treatment and clinical translation for epilepsy. Graphical Abstract
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ISSN:0272-4340
1573-6830
1573-6830
DOI:10.1007/s10571-024-01458-5