Red pigment produced by Zooshikella ganghwensis inhibited the growth of human cancer cell lines and MMP-1 gene expression

A red pigment produced by Zooshikella ganghwensis , was purified by solvent extraction and fractionation. The pigment was identified to be prodigiosin on the basis of spectroscopic data such as 1 H-NMR, 13 C-NMR, DEPT, 2D-NMR, IR, and FAB-MS. Prodigiosin inhibited matrix metalloproteinase-1 gene exp...

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Published inApplied biological chemistry Vol. 59; no. 4; pp. 567 - 571
Main Authors Oh, Eun-Ji, Kwon, Jung-Hwa, Kim, Su-Yeon, In, Seo-Ji, Lee, Dong-Geol, Cha, Mi-Yeon, Kang, Hee-Cheol, Hwang-Bo, Jeon, Lee, Youn-Hyung, Chung, In-Sik, Baek, Nam-In
Format Journal Article
LanguageEnglish
Published Dordrecht Springer Netherlands 01.08.2016
Springer Nature B.V
한국응용생명화학회
Subjects
Applied Microbiology
Biological Techniques
Bioorganic Chemistry
Biotechnology
Cancer
Chemistry
Chemistry and Materials Science
Fractionation
Gene expression
Interstitial collagenase
Matrix metalloproteinase
Matrix metalloproteinases
Metalloproteinase
NMR
Nuclear magnetic resonance
Prodigiosin
Solvent extraction
Tumor cell lines
농학
Matrix metalloproteinase -1
Human cancer cell line
Prodigiosin
Anti-aging activity
Cytotoxic activity
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ISSN2468-0834
2468-0842
DOI10.1007/s13765-016-0196-1

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Summary:A red pigment produced by Zooshikella ganghwensis , was purified by solvent extraction and fractionation. The pigment was identified to be prodigiosin on the basis of spectroscopic data such as 1 H-NMR, 13 C-NMR, DEPT, 2D-NMR, IR, and FAB-MS. Prodigiosin inhibited matrix metalloproteinase-1 gene expression and the growth of human cancer cell lines, SK-BR-3, HCT-116, SK-OV-3, HeLa, HepG2, and SK-MEL-5.
Bibliography:ObjectType-Article-1
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content type line 14
G704-000111.2016.59.4.003
ISSN:2468-0834
2468-0842
DOI:10.1007/s13765-016-0196-1