effect of praziquantel applied per os on selected haematological and biochemical indices in common carp (Cyprinus carpio L.)

• Published in: Fish physiology and biochemistry Vol. 35; no. 4; pp. 599 - 605
• Main Authors: Sudova, Eliska, Piackova, Veronika, Kroupova, Hana, Pijacek, Martin, Svobodova, Zdenka
• Format: Journal Article
• Language: English
• Published: Dordrecht Dordrecht : Springer Netherlands 01.11.2009; Springer Netherlands; Springer Nature B.V
• Subjects: Alanine Transaminase - blood; Analysis of Variance; Animal Anatomy; Animal Biochemistry; Animal Physiology; Animals; Anthelmintics - toxicity; Aquaculture; Aspartate Aminotransferases - blood; Biomedical and Life Sciences; Blood Glucose - analysis; Blood Proteins - analysis; Body weight; Carps - blood; Carps - metabolism; Cyprinus carpio; Erythrocytes - drug effects; Fish; Freshwater; Freshwater & Marine Ecology; Hematocrit - veterinary; Hematology; Histology; Life Sciences; Male; Morphology; Praziquantel - toxicity; Zoology; Biochemistry; Carp; Treatment; Anthelminthic
• ISSN: 0920-1742; 1573-5168
• DOI: 10.1007/s10695-008-9269-3

The aim of the study was to assess the effects of the anthelminthic, praziquantel, on the haematological and biochemical indices of the blood of common carp (Cyprinus carpio L.). Fish were divided into six groups: two groups received 30 mg kg⁻¹ body weight (bw) of praziquantel, and two groups were given 50 mg kg⁻¹ bw of praziquantel mixed into the heat-treated amyloid vehicle. Fish in the remaining two groups were given only the amyloid vehicle and were used as controls. Fish were examined either 24 or 96 h after administration. Praziquantel treatment was characterised by a significantly lower erythrocyte count, haemoglobin level, packed cell volume and total protein at both dose levels after 24 h compared with the controls, but these parameters were similar to the control values at 96 h. The activity of alanine aminotransferase (ALT) was significantly higher after 96 h in the treated groups, which could be attributed to slight hepatocyte damage caused by praziquantel. However, the differences between the treated and the control groups were not great, and we presumed that they were reversible.