Encapsulation of actives for sustained release

Encapsulation of actives in miniature reservoirs, called microcapsules, is used for protection and in particular controlled release of the active. Regarding controlled release applications, the most common function of the microcapsule is to sustain or extend the release of the active. A number of en...

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Published inPhysical chemistry chemical physics : PCCP Vol. 15; no. 41; pp. 17727 - 17741
Main Authors ANDERSSON TROJER, Markus, NORDSTIERNA, Lars, NORDIN, Matias, NYDEN, Magnus, HOLMBERG, Krister
Format Journal Article
LanguageEnglish
Published Cambridge Royal Society of Chemistry 07.11.2013
Subjects
Active control
Brownian motion
Chemistry
Colloidal state and disperse state
Controlled release
Diffusion
Emulsions. Microemulsions. Foams
Encapsulation
Exact sciences and technology
General and physical chemistry
Mathematical models
Miniature
Physical chemistry
Surface physical chemistry
Encapsulation
Methodology
Microcapsule
Multiple layer
Polymerization
Reservoir
Review
Hydrophobicity
Template
Brownian motion
Polyelectrolyte
Emulsion
Adsorption
Morphology
Phase separation
Models
Diffusion
Protection
Interface
Release
Physicochemical properties
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Summary:Encapsulation of actives in miniature reservoirs, called microcapsules, is used for protection and in particular controlled release of the active. Regarding controlled release applications, the most common function of the microcapsule is to sustain or extend the release of the active. A number of encapsulation methodologies are available including; internal phase separation, interfacial polymerization, formation of multiple emulsions, Layer-by-Layer adsorption of polyelectrolytes and soft templating techniques, all of which are reviewed in this Perspective. The choice of method depends on the nature of the active (hydrophilic/hydrophobic, size, physical state) and on the intended release rate and release profile. Ways to manipulate the release of the active by tailoring the physicochemical properties of the microcapsule are reviewed. Moreover, appropriate diffusion models are introduced to describe the release profile from a variety of microcapsule morphologies, including Fickian diffusion models and Brownian motion, and the meaning and the misuse of the term "zero-order release" are briefly discussed.
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ISSN:1463-9076
1463-9084
1463-9084
DOI:10.1039/c3cp52686k